The Relation Between Atherogenic Index of Plasma and Cardiovascular Outcomes in Prediabetic Individuals with Unstable Angina Pectoris

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2023 Aug 31

PMID 37653411

Authors

Yang Liu

Xunxun Feng

JiaQi Yang

Guangyao Zhai

Bin Zhang

Qianyun Guo

Yujie Zhou

Affiliations

Soon will be listed here.

Abstract

Background: The atherogenic index of plasma (AIP) is a novel biomarker associated with atherosclerosis, and an important risk factor for atherosclerosis, but its relation with cardiovascular prognosis in prediabetic patients with unstable angina pectoris (UAP) is still uncertain.

Methods: This study included 1096 prediabetic patients with UAP who were subjected to follow-up for a maximum of 30 months, with cardiac death, refractory angina, and non-fatal myocardial infarction (MI) being the primary cardiovascular endpoints.

Results: A significantly increased AIP was observed for the group with primary cardiovascular endpoints. Kaplan-Meier curves corresponding to these endpoints revealed pronounced differences between these two AIP groups (Log-rank P < 0.001). Multivariate Cox proportional hazards analyses highlighted AIP as being independent related to this primary endpoint (HR 1.308, 95% CI: 1.213-1.412, P < 0.001). AIP addition to the baseline risk model improved the prediction of the primary endpoint (AUC: baseline model, 0.622, vs. baseline model + AIP, 0.739, P < 0.001).

Conclusions: AIP could be used to predict cardiovascular events in prediabetic individuals with UAP.

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