[Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell  Papilloma and Infection with Tropheryma Whipplei: A Case Report]

Overview

Journal Zhongguo Fei Ai Za Zhi

Specialties Oncology
Pulmonary Medicine

Date 2023 Aug 31

PMID 37653019

Authors

Xiaolei Yue

Xiaoxia Xi

Min Zhang

Junyu Bian

Yonglin Chen

Affiliations

Soon will be listed here.

Abstract

Simultaneous multiple primary tumors on the same side of the lung with Tropheryma whipplei (TW) infection are rare. We reviewed the clinical data, imaging manifestations, pathological results, diagnosis and treatment of a primary pulmonary mucinous adenocarcinoma (PPMA) patient with bronchial squamous cell papilloma (BSCP) and TW infection, and discussed our treatment experience. The patient mainly presented with chronic cough and sputum, and computed tomography (CT) showed inflammatory changes with multiple nodular shadows. Biopsy of the lower lobe of the right lung showed PPMA, and right lung sub-branchial nodules discovered during bronchoscope revealed BSCP. Metagenomics next generation sequencing (mNGS) of bronchoalveolar lavage fluid showed mixed infection of Streptococcus pneumoniae and TW with a poor anti-infective effect. No clear genetic mutation was detected, and the patient was treated with chemotherapy and regularly followed up. We should improve the awareness of multiple pulmonary pathologies during clinical practice, avoid missed diagnosis and misdiagnosis, and carry out comprehensive treatment after clarifying the diagnosis as soon as possible. .

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[Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell Papilloma and Infection with Tropheryma Whipplei: A Case Report]

[Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell  Papilloma and Infection with Tropheryma Whipplei: A Case Report]