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Influence of Dairy Products Consumption on Oral Cancer Risk: A Meta-analysis

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Specialty Dentistry
Date 2023 Aug 31
PMID 37650016
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Abstract

Background: The role of dairy product consumption on oral cancer risk is not yet fully clarified. Some studies have observed an inverse association between dairy consumption and oral cancer risk. This study aimed to determine the influence of dairy product consumption (milk, cheese, yogurt, butter) on oral cancer risk.

Methods: A search for studies on dairy products and oral cancer was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Scopus. The estimation of the odds ratio (OR) effect was performed with the generic inverse variance method using the logarithm of the effect with the standard error (SE) and 95% confidence intervals.

Results: Twenty-one studies with 59271 participants (8,300 oral cancer patients and 50971 controls) were included in this meta-analysis. All dairy products significantly reduced oral cancer risk except butter (=0.16). Milk intake reduced oral cancer risk by 27% (OR: 0.73; <0.001); yogurt consumption by 25% (OR: 0.75; <0.001), and cheese consumption by 21% (OR:0.79; <0.01).

Conclusion: Regular consumption of dairy products reduces oral cancer risk between 21% and 27%.

References
1.
Morse D, Pendrys D, Katz R, Holford T, Krutchkoff D, Eisenberg E . Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes Control. 2000; 11(8):713-20. DOI: 10.1023/a:1008943904085. View

2.
Toporcov T, Biazevic M, Rotundo L, de Andrade F, Brasilino de Carvalho M, Brasileiro R . [Consumption of animal-derived foods and mouth and oropharyngeal cancer]. Rev Panam Salud Publica. 2012; 32(3):185-91. DOI: 10.1590/s1020-49892012000900003. View

3.
Panahipour L, Biasi M, Bokor T, Thajer A, Haiden N, Gruber R . Milk lactoperoxidase decreases ID1 and ID3 expression in human oral squamous cell carcinoma cell lines. Sci Rep. 2020; 10(1):5836. PMC: 7125221. DOI: 10.1038/s41598-020-62390-4. View

4.
Fan Y, Qiu Y, Chen Q, Wang S, Wang Y, Li Y . Association Between Dietary Fatty Acid Pattern and Risk of Oral Cancer. Front Nutr. 2022; 9:864098. PMC: 9149618. DOI: 10.3389/fnut.2022.864098. View

5.
Rodriguez-Molinero J, Del Carmen Miguelanez-Medran B, Puente-Gutierrez C, Delgado-Somolinos E, Carreras-Presas C, Fernandez-Farhall J . Association between Oral Cancer and Diet: An Update. Nutrients. 2021; 13(4). PMC: 8071138. DOI: 10.3390/nu13041299. View