Advances in the Roles of Glycyrrhizic Acid in Cancer Therapy

Overview

Journal Front Pharmacol

Date 2023 Aug 31

PMID 37649893

Authors

Yuqian Zhang

Zixuan Sheng

Jing Xiao

Yang Li

Jie Huang

Jinjing Jia

Xiansi Zeng

Li Li

Affiliations

Soon will be listed here.

Abstract

Since the first 70 years of reporting cancer chemotherapy, malignant tumors have been the second most common cause of death in children and adults. Currently, the commonly used anti-cancer methods include surgery, chemotherapy, radiotherapy, and immunotherapy. Although these treatment methods could alleviate cancer, they lead to different forms of side effects and have no particularly significant effect on prolonging the patients' life span. Glycyrrhizic acid (GL), a native Chinese herbal extract, has a wide range of pharmacological effects, such as anti-cancer, anti-inflammatory, antioxidant, and immune regulation. In this review, the anti-cancer effects and mechanisms of GL are summarized in various cancers. The inhibition of GL on chemotherapy-induced side effects, including hepatotoxicity, nephrotoxicity, genotoxicity, neurotoxicity and pulmonary toxicity, is highlighted. Therefore, GL may be a promising and ideal drug for cancer therapy.

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References

Bi X, Yang L, Lin Y, Deng W, Jiang T, Zhang L . Efficacy and Safety of Glycyrrhizic Acid in Treatment of Autoimmune Hepatitis. Am J Chin Med. 2023; 51(2):391-405. DOI: 10.1142/S0192415X23500209. View

Zhou J, Wink M . Reversal of Multidrug Resistance in Human Colon Cancer and Human Leukemia Cells by Three Plant Extracts and Their Major Secondary Metabolites. Medicines (Basel). 2018; 5(4). PMC: 6313689. DOI: 10.3390/medicines5040123. View

Rastogi V, Yadav P, Bhattacharya S, Mishra A, Verma N, Verma A . Carbon nanotubes: an emerging drug carrier for targeting cancer cells. J Drug Deliv. 2014; 2014:670815. PMC: 4020363. DOI: 10.1155/2014/670815. View

Karimi P, Islami F, Anandasabapathy S, Freedman N, Kamangar F . Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014; 23(5):700-13. PMC: 4019373. DOI: 10.1158/1055-9965.EPI-13-1057. View

Li M, Xiang L, Li Y . Efficacy and safety of compound glycyrrhizin in the patients with vitiligo: a systematic review and meta-analysis. Expert Rev Clin Pharmacol. 2023; 16(6):601-611. DOI: 10.1080/17512433.2023.2213887. View

Chen L, Yang J, Davey A, Chen Y, Wang J, Liu X . Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism. Xenobiotica. 2009; 39(12):955-63. DOI: 10.3109/00498250903271997. View

Khan R, Quaiyoom Khan A, Lateef A, Rehman M, Tahir M, Ali F . Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats. PLoS One. 2013; 8(2):e56020. PMC: 3573076. DOI: 10.1371/journal.pone.0056020. View

Hausman D . What Is Cancer?. Perspect Biol Med. 2019; 62(4):778-784. DOI: 10.1353/pbm.2019.0046. View

He S, Gao M, Fu Y, Zhang Y . Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling. Int J Clin Exp Pathol. 2015; 8(5):5175-81. PMC: 4503086. View

10.

Kanzawa T, Ito H, Kondo Y, Kondo S . Current and Future Gene Therapy for Malignant Gliomas. J Biomed Biotechnol. 2003; 2003(1):25-34. PMC: 179758. DOI: 10.1155/S1110724303209013. View

11.

Xu C, Liang C, Sun W, Chen J, Chen X . Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state. Drug Des Devel Ther. 2018; 12:1311-1319. PMC: 5965375. DOI: 10.2147/DDDT.S165225. View

12.

Su X, Wu L, Hu M, Dong W, Xu M, Zhang P . Glycyrrhizic acid: A promising carrier material for anticancer therapy. Biomed Pharmacother. 2017; 95:670-678. DOI: 10.1016/j.biopha.2017.08.123. View

13.

Kishimoto K, Hasegawa D, Uemura S, Nakamura S, Kozaki A, Saito A . Effect of Monoammonium Glycyrrhizinate on the Development of Hepatotoxicity After Initial Intrathecal Chemotherapy for Leukemia. Anticancer Res. 2021; 41(12):6231-6236. DOI: 10.21873/anticanres.15443. View

14.

Wakamatsu T, Nakahashi Y, Hachimine D, Seki T, Okazaki K . The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins. Int J Oncol. 2007; 31(6):1465-72. View

15.

Han Y, Jia Q, Yang D, Chai W, Zhang X, He Q . Current advances in environmental stimuli regulating the glycyrrhizic acid biosynthesis pathway. Fitoterapia. 2021; 151:104860. DOI: 10.1016/j.fitote.2021.104860. View

16.

Qu L, Chen C, Chen Y, Li Y, Tang F, Huang H . High-Mobility Group Box 1 (HMGB1) and Autophagy in Acute Lung Injury (ALI): A Review. Med Sci Monit. 2019; 25:1828-1837. PMC: 6423734. DOI: 10.12659/MSM.912867. View

17.

Li J, Cao H, Liu P, Cheng G, Sun M . Glycyrrhizic acid in the treatment of liver diseases: literature review. Biomed Res Int. 2014; 2014:872139. PMC: 4052927. DOI: 10.1155/2014/872139. View

18.

Maione F, Minosi P, Di Giannuario A, Raucci F, Chini M, De Vita S . Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies. Molecules. 2019; 24(13). PMC: 6651237. DOI: 10.3390/molecules24132453. View

19.

Arwanda M, Haryuna T, Adriztina I, Khalid K . Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE. Iran J Otorhinolaryngol. 2023; 35(129):189-197. PMC: 10368170. DOI: 10.22038/IJORL.2023.71786.3452. View

20.

Gederaas O, Sharma A, Mbarak S, Sporsheim B, Hogset A, Bogoeva V . Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells. Mol Omics. 2023; 19(7):585-597. DOI: 10.1039/d2mo00337f. View