Effects of Dopamine on Stem Cells and Its Potential Roles in the Treatment of Inflammatory Disorders: a Narrative Review

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2023 Aug 30

PMID 37649087

Authors

Guan-Qiao Liu

Zi-Xian Liu

Ze-Xin Lin

Peng Chen

Yu-Chi Yan

Qing-Rong Lin

Yan-Jun Hu

Nan Jiang

Bin Yu

Affiliations

Soon will be listed here.

Abstract

Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient's life. Due to anti-inflammatory effects, corticosteroids, immunosuppressants, and monoclonal antibodies are used to treat various inflammatory diseases, but drug resistance, non-responsiveness, and severe side effect limit their development and application. Therefore, developing other alternative therapies has become essential in anti-inflammatory therapy. In recent years, the in-depth study of stem cells has made them a promising alternative drug for the treatment of inflammatory diseases, and the function of stem cells is regulated by a variety of signals, of which dopamine signaling is one of the main influencing factors. In this review, we review the effects of dopamine on various adult stem cells (neural stem cells, mesenchymal stromal cells, hematopoietic stem cells, and cancer stem cells) and their signaling pathways, as well as the application of some critical dopamine receptor agonists/antagonists. Besides, we also review the role of various adult stem cells in inflammatory diseases and discuss the potential anti-inflammation function of dopamine receptors, which provides a new therapeutic target for regenerative medicine in inflammatory diseases.

Citing Articles

Examining structure-activity relationships of ManNAc analogs used in the metabolic glycoengineering of human neural stem cells.

Dammen-Brower K, Arbogast O, Zhu S, Qiu C, Zhang C, Khare P Biomater Adv. 2025; 169:214144.

PMID: 39754871 PMC: 11884250. DOI: 10.1016/j.bioadv.2024.214144.

Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor.

Ayon-Olivas M, Wolf D, Andreska T, Granado N, Luningschror P, Ip C Biology (Basel). 2023; 12(10).

PMID: 37887070 PMC: 10604681. DOI: 10.3390/biology12101360.

References

Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts A . Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008; 2(2):141-50. DOI: 10.1016/j.stem.2007.11.014. View

Riessland M, Kolisnyk B, Kim T, Cheng J, Ni J, Pearson J . Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell Stem Cell. 2019; 25(4):514-530.e8. PMC: 7493192. DOI: 10.1016/j.stem.2019.08.013. View

Kasper G, Dankert N, Tuischer J, Hoeft M, Gaber T, Glaeser J . Mesenchymal stem cells regulate angiogenesis according to their mechanical environment. Stem Cells. 2007; 25(4):903-10. DOI: 10.1634/stemcells.2006-0432. View

Tonnesen M, Feng X, Clark R . Angiogenesis in wound healing. J Investig Dermatol Symp Proc. 2001; 5(1):40-6. DOI: 10.1046/j.1087-0024.2000.00014.x. View

Coppe J, Desprez P, Krtolica A, Campisi J . The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. PMC: 4166495. DOI: 10.1146/annurev-pathol-121808-102144. View

Nemoto Y, Kanai T, Takahara M, Oshima S, Nakamura T, Okamoto R . Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut. 2012; 62(8):1142-52. PMC: 3711361. DOI: 10.1136/gutjnl-2012-302029. View

Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F . Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity. 2011; 35(2):273-84. DOI: 10.1016/j.immuni.2011.06.011. View

Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk D, Guan D . Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015; 75(6):924-9. PMC: 4359955. DOI: 10.1158/0008-5472.CAN-14-3225. View

Sood N . Prevalence of pseudoexfoliation of the lens capsule in India. Acta Ophthalmol (Copenh). 1968; 46(2):211-4. DOI: 10.1111/j.1755-3768.1968.tb05179.x. View

10.

Kuang Z, Chen Z, Tu S, Mai Z, Chen L, Kang X . Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3/-Catenin Signaling Pathway. Stem Cells Int. 2022; 2022:4154440. PMC: 9259353. DOI: 10.1155/2022/4154440. View

11.

Su J, Chen X, Huang Y, Li W, Li J, Cao K . Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differ. 2013; 21(3):388-96. PMC: 3921585. DOI: 10.1038/cdd.2013.149. View

12.

Rustad K, Wong V, Sorkin M, Glotzbach J, Major M, Rajadas J . Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials. 2011; 33(1):80-90. PMC: 3997302. DOI: 10.1016/j.biomaterials.2011.09.041. View

13.

Hofland L, Feelders R, de Herder W, Lamberts S . Pituitary tumours: the sst/D2 receptors as molecular targets. Mol Cell Endocrinol. 2010; 326(1-2):89-98. DOI: 10.1016/j.mce.2010.04.020. View

14.

Liu D, Kou X, Chen C, Liu S, Liu Y, Yu W . Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors. Cell Res. 2018; 28(9):918-933. PMC: 6123409. DOI: 10.1038/s41422-018-0070-2. View

15.

Moiseeva O, Deschenes-Simard X, St-Germain E, Igelmann S, Huot G, Cadar A . Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation. Aging Cell. 2013; 12(3):489-98. DOI: 10.1111/acel.12075. View

16.

Dolma S, Selvadurai H, Lan X, Lee L, Kushida M, Voisin V . Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016; 29(6):859-873. PMC: 5968455. DOI: 10.1016/j.ccell.2016.05.002. View

17.

Zhang Y, Gao S, Xia J, Liu F . Hematopoietic Hierarchy - An Updated Roadmap. Trends Cell Biol. 2018; 28(12):976-986. DOI: 10.1016/j.tcb.2018.06.001. View

18.

Maffioli E, Nonnis S, Angioni R, Santagata F, Cali B, Zanotti L . Proteomic analysis of the secretome of human bone marrow-derived mesenchymal stem cells primed by pro-inflammatory cytokines. J Proteomics. 2017; 166:115-126. DOI: 10.1016/j.jprot.2017.07.012. View

19.

Wang S, Mou Z, Ma Y, Li J, Li J, Ji X . Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: Involvement of eradicating cancer stem-like cells. Biochem Pharmacol. 2015; 95(2):98-109. DOI: 10.1016/j.bcp.2015.03.013. View

20.

Wu Y, Hu Y, Wang B, Li S, Ma C, Liu X . Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation. Mol Cell. 2020; 78(1):42-56.e6. DOI: 10.1016/j.molcel.2020.01.022. View