Birth Size and the Serum Level of Biological Age Markers in Men

Overview

Journal Sci Rep

Specialty Science

Date 2023 Aug 30

PMID 37648769

Authors

Agnieszka Zelazniewicz

Judyta Nowak-Kornicka

Boguslaw Pawlowski

Affiliations

Soon will be listed here.

Abstract

Previous studies showed that intrauterine growth restrictions, resulting in smaller body size at birth, are associated with altered development and the risk of age-related diseases in adult life. Thus, prenatal development may predict aging trajectories in humans. The study aimed to verify if body size at birth is related to biological age in adult men. The study sample consisted of 159 healthy, non-smoking men with a mean age of 35.24 (SD 3.44) years. Birth weight and length were taken from medical records. The ponderal index at birth was calculated. Biological age was evaluated based on serum levels of s-Klotho, hsCRP, DHEA/S, and oxidative stress markers. Pregnancy age at birth, lifestyle, weight, cortisol, and testosterone levels were controlled. The results showed no relationship between birth size and s-Klotho, DHEA/S level, inflammation, or oxidative stress. Also, men born as small-for-gestational-age (N = 49) and men born as appropriate-for-gestational-age (N = 110) did not differ in terms of biological age markers levels. The results were similar when controlled for pregnancy week at birth, chronological age, BMI, testosterone, or cortisol level. The results suggest that there is no relationship between intrauterine growth and biomarkers of aging in men aged 30-45 years from the affluent population.

References

Yaribeygi H, Sathyapalan T, Atkin S, Sahebkar A . Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev. 2020; 2020:8609213. PMC: 7085395. DOI: 10.1155/2020/8609213. View

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D . Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13:757-772. PMC: 5927356. DOI: 10.2147/CIA.S158513. View

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman A, Montano M . Biomarker signatures of aging. Aging Cell. 2017; 16(2):329-338. PMC: 5334528. DOI: 10.1111/acel.12557. View

Quinn E, Hsiao C, Maisha F, Mulligan C . Low birthweight is associated with epigenetic age acceleration in the first 3 years of life. Evol Med Public Health. 2023; 11(1):251-261. PMC: 10360162. DOI: 10.1093/emph/eoad019. View

Franco M, Kawamoto E, Gorjao R, Rastelli V, Curi R, Scavone C . Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: evidence of lipid peroxidation. Pediatr Res. 2007; 62(2):204-8. DOI: 10.1203/PDR.0b013e3180986d04. View

Goosby B, Cheadle J, McDade T . Birth weight, early life course BMI, and body size change: Chains of risk to adult inflammation?. Soc Sci Med. 2015; 148:102-9. PMC: 4698177. DOI: 10.1016/j.socscimed.2015.11.040. View

Luyckx V, Compston C, Simmen T, Mueller T . Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth. Am J Physiol Renal Physiol. 2009; 297(6):F1697-705. DOI: 10.1152/ajprenal.00462.2009. View

Melzer D, Pilling L, Ferrucci L . The genetics of human ageing. Nat Rev Genet. 2019; 21(2):88-101. PMC: 9934000. DOI: 10.1038/s41576-019-0183-6. View

Amaro-Gahete F, Jurado-Fasoli L, Sanchez-Delgado G, Garcia-Lario J, Castillo M, Ruiz J . Relationship between plasma S-Klotho and cardiometabolic risk in sedentary adults. Aging (Albany NY). 2020; 12(3):2698-2710. PMC: 7041759. DOI: 10.18632/aging.102771. View

10.

Belenguer-Varea A, Tarazona-Santabalbina F, Avellana-Zaragoza J, Martinez-Reig M, Mas-Bargues C, Ingles M . Oxidative stress and exceptional human longevity: Systematic review. Free Radic Biol Med. 2019; 149:51-63. DOI: 10.1016/j.freeradbiomed.2019.09.019. View

11.

Sze L, Bernays R, Zwimpfer C, Wiesli P, Brandle M, Schmid C . Excessively high soluble Klotho in patients with acromegaly. J Intern Med. 2012; 272(1):93-7. DOI: 10.1111/j.1365-2796.2012.02542.x. View

12.

Allvin K, Ankarberg-Lindgren C, Fors H, Dahlgren J . Elevated serum levels of estradiol, dihydrotestosterone, and inhibin B in adult males born small for gestational age. J Clin Endocrinol Metab. 2008; 93(4):1464-9. DOI: 10.1210/jc.2007-1743. View

13.

Tarry-Adkins J, Martin-Gronert M, Chen J, Cripps R, Ozanne S . Maternal diet influences DNA damage, aortic telomere length, oxidative stress, and antioxidant defense capacity in rats. FASEB J. 2008; 22(6):2037-44. DOI: 10.1096/fj.07-099523. View

14.

Wu S, Chen W . Soluble klotho as an effective biomarker to characterize inflammatory states. Ann Med. 2022; 54(1):1520-1529. PMC: 9132391. DOI: 10.1080/07853890.2022.2077428. View

15.

De Martinis M, Franceschi C, Monti D, Ginaldi L . Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol. 2006; 80(3):219-27. DOI: 10.1016/j.yexmp.2005.11.004. View

16.

Masi A, Rehman A, Jorgenson L, Smith J, Aldag J . Sexual Dimorphisms of Adrenal Steroids, Sex Hormones, and Immunological Biomarkers and Possible Risk Factors for Developing Rheumatoid Arthritis. Int J Endocrinol. 2015; 2015:929246. PMC: 4674595. DOI: 10.1155/2015/929246. View

17.

Workman M, Kelly K . Heavier birth weight associated with taller height but not age at menarche in US women born 1991-1998. Am J Hum Biol. 2017; 29(5). DOI: 10.1002/ajhb.22999. View

18.

Megson I, Haw S, Newby D, Pell J . Association between exposure to environmental tobacco smoke and biomarkers of oxidative stress among patients hospitalised with acute myocardial infarction. PLoS One. 2013; 8(12):e81209. PMC: 3855195. DOI: 10.1371/journal.pone.0081209. View

19.

Orces C . The association between metabolic syndrome and the anti-aging humoral factor klotho in middle-aged and older adults. Diabetes Metab Syndr. 2022; 16(6):102522. DOI: 10.1016/j.dsx.2022.102522. View

20.

Quintero-Platt G, Gonzalez-Reimers E, Rodriguez-Gaspar M, Martin-Gonzalez C, Perez-Hernandez O, Romero-Acevedo L . Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics. Alcohol Alcohol. 2017; 52(5):542-549. DOI: 10.1093/alcalc/agx041. View