Predicting the Prognosis of Operable Gastric Cancer Patients by Dynamic Changes in Platelets Before and After Surgery: a Retrospective Cohort Study

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2023 Aug 29

PMID 37642724

Authors

Jiante Li

Xinxin Yang

Xiang Wang

Yiwei Jiang

Zhonglin Wang

Xian Shen

Zhaoshen Li

Affiliations

Soon will be listed here.

Abstract

Purpose: Since the relationship between postoperative platelet count and prognosis is still unclear, we designed a standardized index of platelet count to predict the prognosis of gastric cancer (GC).

Methods: We designed a development validation cohort for the pre/post platelet ratio. We determined the ability of PPR to predict mortality in gastric cancer patients and validated them by a separate cohort. Survival was assessed by Kaplan-Meier analysis and associations explored by multivariate and multivariate analyses. The usefulness of the prediction was estimated by measuring the time-dependent ROC. Decision-curve analysis was used to validate the net clinical benefit.

Results: The sample distribution was similar in the two cohorts, and the 1-, 3-, and 5-year OS evaluation of the postoperative/preoperative platelet ratio was the largest for AUC in the two cohorts. Meanwhile, PPR has a good predictive value and a net clinical benefit.

Conclusions: PPR has been identified and validated to be independently concerned about OS of patients with GC and was a reliable and economic indicator to evaluate the prognosis.

References

Bando E, Makuuchi R, Irino T, Tanizawa Y, Kawamura T, Terashima M . Validation of the prognostic impact of the new tumor-node-metastasis clinical staging in patients with gastric cancer. Gastric Cancer. 2018; 22(1):123-129. DOI: 10.1007/s10120-018-0799-9. View

Beal E, Wei L, Ethun C, Black S, Dillhoff M, Salem A . Elevated NLR in gallbladder cancer and cholangiocarcinoma - making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium. HPB (Oxford). 2016; 18(11):950-957. PMC: 5094484. DOI: 10.1016/j.hpb.2016.08.006. View

Belkouchi Y, Nebot-Bral L, Lawrance L, Kind M, David C, Ammari S . Predicting immunotherapy outcomes in patients with MSI tumors using NLR and CT global tumor volume. Front Oncol. 2022; 12:982790. PMC: 9641225. DOI: 10.3389/fonc.2022.982790. View

Bilgin B, Sendur M, Hizal M, Dede D, Akinci M, Kandil S . Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization. J Cancer Res Ther. 2019; 15(1):54-60. DOI: 10.4103/jcrt.JCRT_624_17. View

Camp R, Dolled-Filhart M, Rimm D . X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004; 10(21):7252-9. DOI: 10.1158/1078-0432.CCR-04-0713. View

Cao H, Tang Z, Yu Z, Wang Q, Li Z, Lu Q . Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems. Oncol Lett. 2019; 17(1):1299-1305. PMC: 6312982. DOI: 10.3892/ol.2018.9694. View

Chen R, Jin G, Li W, McIntyre T . Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition. J Immunol. 2018; 201(7):2154-2164. PMC: 6143412. DOI: 10.4049/jimmunol.1800124. View

Chan L, Wong S, Cho W, Huang M, Zhang F, Chui M . Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography. Diagnostics (Basel). 2023; 13(1). PMC: 9818425. DOI: 10.3390/diagnostics13010102. View

DAmbrosi S, Nilsson R, Wurdinger T . Platelets and tumor-associated RNA transfer. Blood. 2021; 137(23):3181-3191. PMC: 8351881. DOI: 10.1182/blood.2019003978. View

10.

Deppermann C, Kratofil R, Peiseler M, David B, Zindel J, Vargas E Silva Castanheira F . Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets. J Exp Med. 2020; 217(4). PMC: 7144524. DOI: 10.1084/jem.20190723. View

11.

Fukuhara M, Muto S, Inomata S, Yamaguchi H, Mine H, Takagi H . The clinical significance of tertiary lymphoid structure and its relationship with peripheral blood characteristics in patients with surgically resected non-small cell lung cancer: a single-center, retrospective study. Cancer Immunol Immunother. 2021; 71(5):1129-1137. PMC: 10992741. DOI: 10.1007/s00262-021-03067-3. View

12.

Varzideh F, Gambardella J, Kansakar U, Jankauskas S, Santulli G . Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells. Int J Mol Sci. 2023; 24(9). PMC: 10179698. DOI: 10.3390/ijms24098386. View

13.

Gao T, Yu Y, Cong Q, Wang Y, Sun M, Yao L . Human mesenchymal stem cells in the tumour microenvironment promote ovarian cancer progression: the role of platelet-activating factor. BMC Cancer. 2018; 18(1):999. PMC: 6241787. DOI: 10.1186/s12885-018-4918-0. View

14.

Gao Y, Wu X, Li Y, Li Y, Zhou Q, Wang Q . The Predictive Value of MLR for Radiation Pneumonia During Radiotherapy of Thoracic Tumor Patients. Cancer Manag Res. 2020; 12:8695-8701. PMC: 7518777. DOI: 10.2147/CMAR.S268964. View

15.

Kostromina M, Tukhovskaya E, Shaykhutdinova E, Slashcheva G, Ismailova A, Palikov V . Screening of the Promising Direct Thrombin Inhibitors from Haematophagous Organisms. Part I: Recombinant Analogues and Their Antithrombotic Activity In Vitro. Biomedicines. 2022; 10(1). PMC: 8772750. DOI: 10.3390/biomedicines10010011. View

16.

Haemmerle M, Stone R, Menter D, Afshar-Kharghan V, Sood A . The Platelet Lifeline to Cancer: Challenges and Opportunities. Cancer Cell. 2018; 33(6):965-983. PMC: 5997503. DOI: 10.1016/j.ccell.2018.03.002. View

17.

Lin J, Desiderio J, Lin J, Wang W, Tu R, Li P . Multicenter Validation Study of the American Joint Commission on Cancer (8th Edition) for Gastric Cancer: Proposal for a Simplified and Improved TNM Staging System. J Cancer. 2020; 11(12):3483-3491. PMC: 7150461. DOI: 10.7150/jca.36891. View

18.

Onagi H, Horimoto Y, Sakaguchi A, Ikarashi D, Yanagisawa N, Nakayama T . High platelet-to-lymphocyte ratios in triple-negative breast cancer associates with immunosuppressive status of TILs. Breast Cancer Res. 2022; 24(1):67. PMC: 9552414. DOI: 10.1186/s13058-022-01563-7. View

19.

Rachidi S, Li H, Wallace K, Li Z, Balch C, Lautenschlaeger T . Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study. Platelets. 2019; 31(1):79-87. DOI: 10.1080/09537104.2019.1573977. View

20.

Chen J, Wang F, Gao S, Yang Y, Zhao Z, Shi J . Surgical outcomes of laparoscopic proximal gastrectomy for upper-third gastric cancer: esophagogastrostomy, gastric tube reconstruction, and double-tract reconstruction. BMC Surg. 2023; 23(1):309. PMC: 10571476. DOI: 10.1186/s12893-023-02219-9. View