» Articles » PMID: 37638148

Pattern of Post COVID Fatigue in Elderly Patients

Overview
Publisher Sage Publications
Date 2023 Aug 28
PMID 37638148
Authors
Affiliations
Soon will be listed here.
Abstract

The incidence of Long COVID (LC) increases with age but then drops sharply in over 70-year-olds. The prevailing explanation is that different biases in data collection such as reluctance to report symptoms or attributing them to comorbidities may explain this pattern in this age group. Our local data suggested a similar pattern confirming the rarity of LC symptoms especially fatigue in the over 70s. Our data have also showed a different phenotype of post COVID fatigue which is not commonly associated with post exertional symptoms bringing into question the suggestion that bias in collecting data is the main cause. We explore several immunological, metabolic and epigenetic factors associated with aging that may explain such phenomenon.

References
1.
Scheibenbogen C, Loebel M, Freitag H, Krueger A, Bauer S, Antelmann M . Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME. PLoS One. 2018; 13(3):e0193672. PMC: 5854315. DOI: 10.1371/journal.pone.0193672. View

2.
Lim E, Ahn Y, Jang E, Lee S, Lee S, Son C . Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020; 18(1):100. PMC: 7038594. DOI: 10.1186/s12967-020-02269-0. View

3.
Twomey R, DeMars J, Franklin K, Culos-Reed S, Weatherald J, Wrightson J . Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study. Phys Ther. 2022; 102(4). PMC: 9383197. DOI: 10.1093/ptj/pzac005. View

4.
Martimbianco A, Pacheco R, Maria Bagattini A, Riera R . Frequency, signs and symptoms, and criteria adopted for long COVID-19: A systematic review. Int J Clin Pract. 2021; 75(10):e14357. PMC: 8236920. DOI: 10.1111/ijcp.14357. View

5.
Mansell V, Dykgraaf S, Kidd M, Goodyear-Smith F . Long COVID and older people. Lancet Healthy Longev. 2022; 3(12):e849-e854. DOI: 10.1016/S2666-7568(22)00245-8. View