Adamantyl-ureas with Pyrazoles Substituted by Fluoroalkanes As Soluble Epoxide Hydrolase Inhibitors

Overview

Journal J Fluor Chem

Specialty Chemistry

Date 2023 Aug 28

PMID 37638129

Authors

Vladimir V Burmistrov

Christophe Morisseau

Tatyana K Shkineva

Dmitry V Danilov

Boris Gladkikh

Gennady M Butov

Robert R Fayzullin

Tatyana Ya Dutova

Bruce D Hammock

Igor L Dalinger

Affiliations

Soon will be listed here.

Abstract

A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (, IC = 0.8 nM) and 1-[(Adamantan-1-yl)methyl]-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (, IC = 1.2 nM) were found to be the most potent sEH inhibitors within the described series.

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