CuH-Catalyzed Selective N-Methylation of Amines Using Paraformaldehyde As a C1 Source

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Aug 28

PMID 37636962

Authors

Diedie Wang

Wanglv Lang

Wan Wang

Qizhuang Zou

Chunliang Yang

Fei Liu

Tianxiang Zhao

Affiliations

Soon will be listed here.

Abstract

Copper hydride (CuH) complexes have been proposed as key intermediates in synthesis and catalysis. Herein, we developed a highly efficient strategy for CuH-catalyzed N-methylation of aromatic and aliphatic amines using paraformaldehyde and polymethylhydrosiloxane (PMHS) under mild reaction conditions. The reaction proceeded smoothly without additives to furnish the corresponding N-methylated products using cyclic(alkyl)(amino)carbene (CAAC)CuH as a reaction intermediate, which results from a reaction between PMHS and (CAAC)CuCl.

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