Sleep Disturbance in Tourette's Disorder: Potential Underlying Mechanisms

Overview

Journal Curr Sleep Med Rep

Specialty General Medicine

Date 2023 Aug 28

PMID 37636897

Authors

Emily J Ricketts

Valerie Swisher

Deanna J Greene

Daniel Silverman

Eric A Nofzinger

Christopher S Colwell

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Sleep disturbance is common in TD. However, our understanding of the pathophysiological mechanisms involved is preliminary. This review summarizes findings from neuroimaging, genetic, and animal studies to elucidate potential underlying mechanisms of sleep disruption in TD.

Recent Findings: Preliminary neuroimaging research indicates increased activity in the premotor cortex, and decreased activity in the prefrontal cortex is associated with NREM sleep in TD. Striatal dopamine exhibits a circadian rhythm; and is influenced by the suprachiasmatic nucleus via multiple molecular mechanisms. Conversely, dopamine receptors regulate circadian function and striatal expression of circadian genes. The association of TD with restless legs syndrome and periodic limb movements indicates shared pathophysiology, including iron deficiency, and variants in the gene. A mutations in the gene in TD, suggests the involvement of the histaminergic system, implicated in arousal, in TD.

Summary: These biological markers have implications for application of novel, targeted interventions, including noninvasive neuromodulation, iron supplementation, histamine receptor antagonists, and circadian-based therapies for tic symptoms and/or sleep and circadian rhythms in TD.

Citing Articles

Contextual Triggers and Tic Severity Across Life Periods: A Retrospective Analysis in Adults with Tic Disorders.

Barber K, Ding Q, Espil F, Woods D, Specht M, Bennett S Child Psychiatry Hum Dev. 2024; .

PMID: 38976153 DOI: 10.1007/s10578-024-01733-y.

References

Himle M, Capriotti M, Hayes L, Ramanujam K, Scahill L, Sukhodolsky D . Variables Associated With Tic Exacerbation in Children With Chronic Tic Disorders. Behav Modif. 2014; 38(2):163-83. PMC: 4211980. DOI: 10.1177/0145445514531016. View

Grippo R, Purohit A, Zhang Q, Zweifel L, Guler A . Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment. Curr Biol. 2017; 27(16):2465-2475.e3. PMC: 5568465. DOI: 10.1016/j.cub.2017.06.084. View

Blake M, Schwartz O, Waloszek J, Raniti M, Simmons J, Murray G . The SENSE Study: Treatment Mechanisms of a Cognitive Behavioral and Mindfulness-Based Group Sleep Improvement Intervention for At-Risk Adolescents. Sleep. 2017; 40(6). DOI: 10.1093/sleep/zsx061. View

Robertson M, Eapen V, Singer H, Martino D, Scharf J, Paschou P . Gilles de la Tourette syndrome. Nat Rev Dis Primers. 2017; 3:16097. DOI: 10.1038/nrdp.2016.97. View

Nofzinger E, Mintun M, Price J, Meltzer C, Townsend D, Buysse D . A method for the assessment of the functional neuroanatomy of human sleep using FDG PET. Brain Res Brain Res Protoc. 1998; 2(3):191-8. DOI: 10.1016/s1385-299x(97)00042-1. View

Thomas M, Sing H, Belenky G, Holcomb H, Mayberg H, Dannals R . Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res. 2000; 9(4):335-52. DOI: 10.1046/j.1365-2869.2000.00225.x. View

Salanitro M, Wrigley T, Ghabra H, de Haan E, Hill C, Solmi M . Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2022; 139:104723. DOI: 10.1016/j.neubiorev.2022.104723. View

Vinner Harduf E, Matzner A, Belelovsky K, Bar-Gad I . Dissociation of tic generation from tic expression during the sleep-wake cycle. iScience. 2021; 24(4):102380. PMC: 8081921. DOI: 10.1016/j.isci.2021.102380. View

Shan L, Dauvilliers Y, Siegel J . Interactions of the histamine and hypocretin systems in CNS disorders. Nat Rev Neurol. 2015; 11(7):401-13. PMC: 8744538. DOI: 10.1038/nrneurol.2015.99. View

10.

Rapanelli M, Pittenger C . Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions. Neuropharmacology. 2015; 106:85-90. DOI: 10.1016/j.neuropharm.2015.08.019. View

11.

Brinkhuijsen M, Koenegracht F, Meesters Y . Symptoms of seasonal affective disorder and of obsessive-compulsive disorder reduced by light therapy. J Affect Disord. 2003; 74(3):307-8. DOI: 10.1016/s0165-0327(03)00003-x. View

12.

Natsubori A, Honma K, Honma S . Dual regulation of clock gene Per2 expression in discrete brain areas by the circadian pacemaker and methamphetamine-induced oscillator in rats. Eur J Neurosci. 2014; 39(2):229-40. DOI: 10.1111/ejn.12400. View

13.

Hibberd C, Charman T, Bhatoa R, Tekes S, Hedderly T, Gringras P . Sleep difficulties in children with Tourette syndrome and chronic tic disorders: a systematic review of characteristics and associated factors. Sleep. 2019; 43(6). DOI: 10.1093/sleep/zsz308. View

14.

Ganos C . Tics and Tourette's: update on pathophysiology and tic control. Curr Opin Neurol. 2016; 29(4):513-8. DOI: 10.1097/WCO.0000000000000356. View

15.

Huang Z, Liang P, Jia X, Zhan S, Li N, Ding Y . Abnormal amygdala connectivity in patients with primary insomnia: evidence from resting state fMRI. Eur J Radiol. 2011; 81(6):1288-95. DOI: 10.1016/j.ejrad.2011.03.029. View

16.

Bloch M, Leckman J . Clinical course of Tourette syndrome. J Psychosom Res. 2009; 67(6):497-501. PMC: 3974606. DOI: 10.1016/j.jpsychores.2009.09.002. View

17.

Uz T, Arslan A, Kurtuncu M, Imbesi M, Akhisaroglu M, Dwivedi Y . The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system. Brain Res Mol Brain Res. 2005; 136(1-2):45-53. DOI: 10.1016/j.molbrainres.2005.01.002. View

18.

Kirov R, Brand S, Banaschewski T, Rothenberger A . Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children. Front Psychol. 2017; 7:2059. PMC: 5220062. DOI: 10.3389/fpsyg.2016.02059. View

19.

Earley C, Jones B, Ferre S . Brain-iron deficiency models of restless legs syndrome. Exp Neurol. 2022; 356:114158. PMC: 9357217. DOI: 10.1016/j.expneurol.2022.114158. View

20.

Hastings M, Maywood E, Brancaccio M . Generation of circadian rhythms in the suprachiasmatic nucleus. Nat Rev Neurosci. 2018; 19(8):453-469. DOI: 10.1038/s41583-018-0026-z. View