Circular RNAs: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression

Overview

Journal EXCLI J

Specialty Biology

Date 2023 Aug 28

PMID 37636026

Authors

Mina Alimohammadi

Yasaman Gholinezhad

Vahide Mousavi

Samaneh Kahkesh

Malihe Rezaee

Alireza Yaghoobi

Alireza Mafi

Mahmood Araghi

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/β-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/β-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches.

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