Therapeutic Effects of Different Intervention Forms of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Osteoarthritis

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Aug 28

PMID 37635870

Authors

Yuelong Zhang

Huangming Zhuang

Xunshan Ren

Fuze Jiang

Panghu Zhou

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is a common and disabling disease. For advanced OA, surgical treatment is still the main treatment. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells, that coordinate cartilage regeneration by secreting various trophic factors, which adjust the injured tissue environment. hUC-MSCs secret extracellular vesicles and participates in OA treatment by transmitting bioactive molecules related to migration, proliferation, apoptosis, inflammatory reaction, extracellular matrix synthesis and cartilage repair. In addition, the combination of multiple substances represented by cartilage matrix and hUC-MSCs also have a significant synergistic effect on OA treatment. Because hUC-MSCs have shown considerable promise in cartilage repair, some scholars have proposed transplanting mesenchymal stem cells into damaged cartilage to delay OA progression. This article reviews the application of hUC-MSCs as a treatment for OA. With the continuous development of routine clinical applications, more reliable intervention modalities for hUC-MSCs in OA treatment will be discovered for the time to come.

Citing Articles

Therapeutic role of extracellular vesicles from human umbilical cord mesenchymal stem cells and their wide therapeutic implications in inflammatory bowel disease and other inflammatory disorder.

Azhar Ud Din M, Wan A, Chu Y, Zhou J, Yan Y, Xu Z Front Med (Lausanne). 2024; 11:1406547.

PMID: 39139783 PMC: 11319305. DOI: 10.3389/fmed.2024.1406547.

References

Wang Y, Deng P, Liu Y, Wu Y, Chen Y, Guo Y . Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat Commun. 2020; 11(1):5596. PMC: 7645772. DOI: 10.1038/s41467-020-19360-1. View

Zhou H, Shen X, Yan C, Xiong W, Ma Z, Tan Z . Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage. Stem Cell Res Ther. 2022; 13(1):322. PMC: 9288728. DOI: 10.1186/s13287-022-03005-9. View

Koliaraki V, Prados A, Armaka M, Kollias G . The mesenchymal context in inflammation, immunity and cancer. Nat Immunol. 2020; 21(9):974-982. DOI: 10.1038/s41590-020-0741-2. View

Lee O, Kuo T, Chen W, Lee K, Hsieh S, Chen T . Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood. 2003; 103(5):1669-75. DOI: 10.1182/blood-2003-05-1670. View

Rakic R, Bourdon B, Demoor M, Maddens S, Saulnier N, Galera P . Differences in the intrinsic chondrogenic potential of equine umbilical cord matrix and cord blood mesenchymal stromal/stem cells for cartilage regeneration. Sci Rep. 2018; 8(1):13799. PMC: 6138671. DOI: 10.1038/s41598-018-28164-9. View

Deyle G, Allen C, Allison S, Gill N, Hando B, Petersen E . Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. N Engl J Med. 2020; 382(15):1420-1429. DOI: 10.1056/NEJMoa1905877. View

Levoux J, Prola A, Lafuste P, Gervais M, Chevallier N, Koumaiha Z . Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming. Cell Metab. 2021; 33(3):688-690. DOI: 10.1016/j.cmet.2021.02.003. View

Akgun I, Unlu M, Erdal O, Ogut T, Erturk M, Ovali E . Matrix-induced autologous mesenchymal stem cell implantation versus matrix-induced autologous chondrocyte implantation in the treatment of chondral defects of the knee: a 2-year randomized study. Arch Orthop Trauma Surg. 2014; 135(2):251-263. DOI: 10.1007/s00402-014-2136-z. View

Kim M, Ahn J, Lee J, Song S, Lee S, Kang K . Combined Mesenchymal Stem Cells and Cartilage Acellular Matrix Injection Therapy for Osteoarthritis in Goats. Tissue Eng Regen Med. 2022; 19(1):177-187. PMC: 8782990. DOI: 10.1007/s13770-021-00407-3. View

10.

Liu C, Xiong Q, Li Q, Lin W, Jiang S, Zhang D . CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling. Nat Commun. 2022; 13(1):1989. PMC: 9007978. DOI: 10.1038/s41467-022-29633-6. View

11.

Xu X, Liang Y, Li X, Ouyang K, Wang M, Cao T . Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration. Biomaterials. 2020; 269:120539. DOI: 10.1016/j.biomaterials.2020.120539. View

12.

Jin S, He D, Luo D, Wang Y, Yu M, Guan B . A Biomimetic Hierarchical Nanointerface Orchestrates Macrophage Polarization and Mesenchymal Stem Cell Recruitment To Promote Endogenous Bone Regeneration. ACS Nano. 2019; 13(6):6581-6595. DOI: 10.1021/acsnano.9b00489. View

13.

Bharti D, Shivakumar S, Park J, Ullah I, Subbarao R, Park J . Comparative analysis of human Wharton's jelly mesenchymal stem cells derived from different parts of the same umbilical cord. Cell Tissue Res. 2017; 372(1):51-65. PMC: 5862947. DOI: 10.1007/s00441-017-2699-4. View

14.

Perry J, Roelofs A, Mennan C, McCarthy H, Richmond A, Clark S . Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. Cells. 2021; 10(8). PMC: 8393840. DOI: 10.3390/cells10081999. View

15.

Tong W, Zhang X, Zhang Q, Fang J, Liu Y, Shao Z . Multiple umbilical cord-derived MSCs administrations attenuate rat osteoarthritis progression via preserving articular cartilage superficial layer cells and inhibiting synovitis. J Orthop Translat. 2020; 23:21-28. PMC: 7235619. DOI: 10.1016/j.jot.2020.03.007. View

16.

Fan J, Lee C, Kim S, Chen C, Aghaloo T, Lee M . Generation of Small RNA-Modulated Exosome Mimetics for Bone Regeneration. ACS Nano. 2020; 14(9):11973-11984. PMC: 7530137. DOI: 10.1021/acsnano.0c05122. View

17.

Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X . Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α. Nat Med. 2011; 17(12):1594-601. PMC: 3233650. DOI: 10.1038/nm.2542. View

18.

Liu D, Kou X, Chen C, Liu S, Liu Y, Yu W . Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors. Cell Res. 2018; 28(9):918-933. PMC: 6123409. DOI: 10.1038/s41422-018-0070-2. View

19.

Li X, Wang Y, Cai Z, Zhou Q, Li L, Fu P . Exosomes from human umbilical cord mesenchymal stem cells inhibit ROS production and cell apoptosis in human articular chondrocytes via the miR-100-5p/NOX4 axis. Cell Biol Int. 2021; 45(10):2096-2106. DOI: 10.1002/cbin.11657. View

20.

Lim H, Park Y, Ha C, Cole B, Lee B, Jeong H . Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cell Implantation Versus Microfracture for Large, Full-Thickness Cartilage Defects in Older Patients: A Multicenter Randomized Clinical Trial and Extended 5-Year Clinical Follow-up. Orthop J Sports Med. 2021; 9(1):2325967120973052. PMC: 7809531. DOI: 10.1177/2325967120973052. View