SIgA in Various Pulmonary Diseases

Overview

Journal Eur J Med Res

Publisher Biomed Central

Specialty General Medicine

Date 2023 Aug 27

PMID 37635240

Authors

Xintian Wang

Jun Zhang

Yan Wu

Yuncong Xu

Jinxu Zheng

Affiliations

Soon will be listed here.

Abstract

Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes among mucosa, which plays an indispensable role in the first-line protection against invading pathogens and antigens. Therefore, the role of respiratory SIgA in respiratory mucosal immune diseases has attracted more and more attention. Although the role of SIgA in intestinal mucosal immunity has been widely studied, the cell types responsible for SIgA and the interactions between cells are still unclear. Here, we conducted a wide search of relevant studies and sorted out the relationship between SIgA and some pulmonary diseases (COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, lung cancer), which found SIgA is involved in the pathogenesis and progression of various lung diseases, intending to provide new ideas for the prevention, diagnosis, and treatment of related lung diseases.

Citing Articles

Immunological Insights and Therapeutic Advances in COPD: Exploring Oral Bacterial Vaccines for Immune Modulation and Clinical Improvement.

Lewicki S, Balan B, Stelmasiak M, Radomska-Lesniewska D, Szymanski L, Rios-Turek N Vaccines (Basel). 2025; 13(2).

PMID: 40006655 PMC: 11861055. DOI: 10.3390/vaccines13020107.

Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2.

Malaspina P, Jodice C, Ciminelli B, Biancolella M, Colona V, Latini A Hum Genomics. 2025; 19(1):7.

PMID: 39885568 PMC: 11780896. DOI: 10.1186/s40246-025-00719-8.

Comprehensive analyses of immune activity in COVID-19-vaccinated idiopathic pulmonary fibrosis patients.

Maciejewska A, Czernia P, Piotrowska-Mieczkowska M, Wajda B, Slominski B, Romantowski J Front Immunol. 2025; 15():1436491.

PMID: 39845961 PMC: 11750670. DOI: 10.3389/fimmu.2024.1436491.

The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease.

Song X, Dou X, Chang J, Zeng X, Xu Q, Xu C Gut Microbes. 2024; 16(1):2414805.

PMID: 39446051 PMC: 11509012. DOI: 10.1080/19490976.2024.2414805.

Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches.

Kim Y, Sohn K, Kang H Korean J Intern Med. 2024; 39(5):746-758.

PMID: 39252487 PMC: 11384250. DOI: 10.3904/kjim.2023.451.

References

De Fays C, Carlier F, Gohy S, Pilette C . Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases. Cells. 2022; 11(8). PMC: 9027823. DOI: 10.3390/cells11081324. View

Li Y, Jin L, Chen T . The Effects of Secretory IgA in the Mucosal Immune System. Biomed Res Int. 2020; 2020:2032057. PMC: 6970489. DOI: 10.1155/2020/2032057. View

Kaetzel C, Mestecky J, Johansen F . Two Cells, One Antibody: The Discovery of the Cellular Origins and Transport of Secretory IgA. J Immunol. 2017; 198(5):1765-1767. DOI: 10.4049/jimmunol.1700025. View

Johansen F, Kaetzel C . Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunol. 2011; 4(6):598-602. PMC: 3196803. DOI: 10.1038/mi.2011.37. View

Rees F, Doherty M, Grainge M, Lanyon P, Zhang W . The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies. Rheumatology (Oxford). 2017; 56(11):1945-1961. DOI: 10.1093/rheumatology/kex260. View

Suzuki K, Nakajima A . New aspects of IgA synthesis in the gut. Int Immunol. 2014; 26(9):489-94. DOI: 10.1093/intimm/dxu059. View

Suzuki K, Fagarasan S . Diverse regulatory pathways for IgA synthesis in the gut. Mucosal Immunol. 2009; 2(6):468-71. DOI: 10.1038/mi.2009.107. View

Salerno-Goncalves R, Safavie F, Fasano A, Sztein M . Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial cell responses. Clin Exp Immunol. 2016; 185(3):338-47. PMC: 4991520. DOI: 10.1111/cei.12801. View

Sheng X, Guo Y, Tang Q, Tang X, Xing J, Chi H . Upregulation of polymeric immunoglobulin receptor expression in flounder (Paralichthys olivaceus) gill cells by cytokine tumor necrosis factor-α via activating PI3K and NF-κB signaling pathways. Mol Immunol. 2021; 135:170-182. DOI: 10.1016/j.molimm.2021.04.011. View

10.

Spencer J, Sollid L . The human intestinal B-cell response. Mucosal Immunol. 2016; 9(5):1113-24. DOI: 10.1038/mi.2016.59. View

11.

Yoshino Y, Yamamoto A, Misu K, Wakabayashi Y, Kitazawa T, Ota Y . Exposure to low temperatures suppresses the production of B-cell activating factor via TLR3 in BEAS-2B cells. Biochem Biophys Rep. 2020; 24:100809. PMC: 7474404. DOI: 10.1016/j.bbrep.2020.100809. View

12.

Davis J, Wypych T . Cellular and functional heterogeneity of the airway epithelium. Mucosal Immunol. 2021; 14(5):978-990. PMC: 7893625. DOI: 10.1038/s41385-020-00370-7. View

13.

Gohy S, Hupin C, Ladjemi M, Hox V, Pilette C . Key role of the epithelium in chronic upper airways diseases. Clin Exp Allergy. 2019; 50(2):135-146. DOI: 10.1111/cea.13539. View

14.

Travaglini K, Nabhan A, Penland L, Sinha R, Gillich A, Sit R . A molecular cell atlas of the human lung from single-cell RNA sequencing. Nature. 2020; 587(7835):619-625. PMC: 7704697. DOI: 10.1038/s41586-020-2922-4. View

15.

Knight D, Holgate S . The airway epithelium: structural and functional properties in health and disease. Respirology. 2004; 8(4):432-46. DOI: 10.1046/j.1440-1843.2003.00493.x. View

16.

Boers J, Ambergen A, Thunnissen F . Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am J Respir Crit Care Med. 1998; 157(6 Pt 1):2000-6. DOI: 10.1164/ajrccm.157.6.9707011. View

17.

Rock J, Randell S, Hogan B . Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech. 2010; 3(9-10):545-56. PMC: 2931533. DOI: 10.1242/dmm.006031. View

18.

Hogan B, Barkauskas C, Chapman H, Epstein J, Jain R, Hsia C . Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014; 15(2):123-38. PMC: 4212493. DOI: 10.1016/j.stem.2014.07.012. View

19.

Zuo W, Shenoy S, Li S, OBeirne S, Strulovici-Barel Y, Leopold P . Ontogeny and Biology of Human Small Airway Epithelial Club Cells. Am J Respir Crit Care Med. 2018; 198(11):1375-1388. PMC: 6290945. DOI: 10.1164/rccm.201710-2107OC. View

20.

Hiemstra P, Bourdin A . Club cells, CC10 and self-control at the epithelial surface. Eur Respir J. 2014; 44(4):831-2. DOI: 10.1183/09031936.00089214. View