Infection, Allergy, and Inflammation: The Role of in Cystic Fibrosis

Overview

Journal Microorganisms

Specialty Microbiology

Date 2023 Aug 26

PMID 37630573

Authors

T Spencer Poore

Edith T Zemanick

Affiliations

Soon will be listed here.

Abstract

(Af) is a mold frequently detected in airway samples from people with cystic fibrosis (pwCF). Abnormal airway mucus may allow Af to germinate, resulting in airway infection or an allergic response. While Af is known to increase morbidity in pwCF, individual responses and the degree of impact on lung disease vary. Improved approaches to diagnosis, treatment, and prevention of Af, particularly the persistent Af infection, are needed. This update highlights our current understanding of Af pathophysiology in the CF airway, the effects of Af on pwCF, and areas of research needed to improve clinical outcomes.

Citing Articles

Respiratory Outcomes and Aspergillus Serology Following Elexacaftor/Tezacaftor/Ivacaftor Therapy in People with Cystic Fibrosis and a History of Aspergillus fumigatus Infection.

Lanfranchi C, Alicandro G, Cariani L, Orena B, Gramegna A, Rizza C Lung. 2025; 203(1):24.

PMID: 39762638 DOI: 10.1007/s00408-024-00781-4.

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