Clinical and Therapeutic Implications of Male Obesity

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Aug 26

PMID 37629396

Authors

Monika Lenart-Lipinska

Michal Luniewski

Joanna Szydelko

Beata Matyjaszek-Matuszek

Affiliations

Soon will be listed here.

Abstract

The prevalence of obesity, a disorder linked to numerous comorbidities and metabolic complications, has recently increased dramatically worldwide and is highly prevalent in men, even at a young age. Compared to female patients, men with obesity more frequently have delayed diagnosis, higher severity of obesity, increased mortality rate, and only a minority of obese male patients are successfully treated, including with bariatric surgery. The aim of this review was to present the current state of knowledge about the clinical and therapeutic implications of obesity diagnosed in males.

Citing Articles

Tryptophan Metabolism in Obesity: The Indoleamine 2,3-Dioxygenase-1 Activity and Therapeutic Options.

Engin A, Engin A Adv Exp Med Biol. 2024; 1460:629-655.

PMID: 39287867 DOI: 10.1007/978-3-031-63657-8_21.

Management of male obesity-related secondary hypogonadism: A clinical update.

Shenoy M, Mondal S, Fernandez C, Pappachan J World J Exp Med. 2024; 14(2):93689.

PMID: 38948417 PMC: 11212738. DOI: 10.5493/wjem.v14.i2.93689.

References

Parent A, Lebrethon M, Gerard A, Vandersmissen E, Bourguignon J . Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y. Regul Pept. 2000; 92(1-3):17-24. DOI: 10.1016/s0167-0115(00)00144-0. View

Yeo G, Farooqi I, Aminian S, Halsall D, Stanhope R, ORahilly S . A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet. 1998; 20(2):111-2. DOI: 10.1038/2404. View

Muller T, Clemmensen C, Finan B, DiMarchi R, Tschop M . Anti-Obesity Therapy: from Rainbow Pills to Polyagonists. Pharmacol Rev. 2018; 70(4):712-746. DOI: 10.1124/pr.117.014803. View

Greig S, Keating G . Naltrexone ER/Bupropion ER: A Review in Obesity Management. Drugs. 2015; 75(11):1269-80. DOI: 10.1007/s40265-015-0427-5. View

Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S . TNF-alpha, soluble TNF receptor and interleukin-6 plasma levels in the general population. Eur Cytokine Netw. 2006; 17(3):196-201. View

Sermondade N, Faure C, Fezeu L, Shayeb A, Bonde J, Jensen T . BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2012; 19(3):221-31. PMC: 3621293. DOI: 10.1093/humupd/dms050. View

Saltiel A, Olefsky J . Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017; 127(1):1-4. PMC: 5199709. DOI: 10.1172/JCI92035. View

Kochkodan J, Telem D, Ghaferi A . Physiologic and psychological gender differences in bariatric surgery. Surg Endosc. 2017; 32(3):1382-1388. DOI: 10.1007/s00464-017-5819-z. View

Striegel-Moore R, Rosselli F, Perrin N, DeBar L, Wilson G, May A . Gender difference in the prevalence of eating disorder symptoms. Int J Eat Disord. 2008; 42(5):471-4. PMC: 2696560. DOI: 10.1002/eat.20625. View

10.

Harris E . Triple-Hormone Combination Retatrutide Induces 24% Body Weight Loss. JAMA. 2023; 330(4):306. DOI: 10.1001/jama.2023.12055. View

11.

Pan Y, Zhang X . Diet and gut microbiome in fatty liver and its associated liver cancer. J Gastroenterol Hepatol. 2021; 37(1):7-14. DOI: 10.1111/jgh.15713. View

12.

Culbert K, Shope M, Sisk C, Klump K . Low testosterone is associated with dysregulated eating symptoms in young adult men. Int J Eat Disord. 2020; 53(9):1469-1479. DOI: 10.1002/eat.23320. View

13.

Chen W, Balland E, Cowley M . Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis. Neuroendocrinology. 2017; 104(4):364-381. DOI: 10.1159/000455865. View

14.

Collet T, Dubern B, Mokrosinski J, Connors H, Keogh J, Mendes de Oliveira E . Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency. Mol Metab. 2017; 6(10):1321-1329. PMC: 5641599. DOI: 10.1016/j.molmet.2017.06.015. View

15.

Wharton S, Lau D, Vallis M, Sharma A, Biertho L, Campbell-Scherer D . Obesity in adults: a clinical practice guideline. CMAJ. 2020; 192(31):E875-E891. PMC: 7828878. DOI: 10.1503/cmaj.191707. View

16.

Lovejoy J, Sainsbury A . Sex differences in obesity and the regulation of energy homeostasis. Obes Rev. 2008; 10(2):154-67. DOI: 10.1111/j.1467-789X.2008.00529.x. View

17.

Ghanim H, Dhindsa S, Abuaysheh S, Batra M, Kuhadiya N, Makdissi A . Diminished androgen and estrogen receptors and aromatase levels in hypogonadal diabetic men: reversal with testosterone. Eur J Endocrinol. 2018; 178(3):277-283. DOI: 10.1530/EJE-17-0673. View

18.

Dhindsa S, Miller M, McWhirter C, Mager D, Ghanim H, Chaudhuri A . Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care. 2010; 33(6):1186-92. PMC: 2875421. DOI: 10.2337/dc09-1649. View

19.

Spieker E, Pyzocha N . Economic Impact of Obesity. Prim Care. 2016; 43(1):83-95, viii-ix. DOI: 10.1016/j.pop.2015.08.013. View

20.

Corona G, Rastrelli G, Monami M, Saad F, Luconi M, Lucchese M . Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol. 2013; 168(6):829-43. DOI: 10.1530/EJE-12-0955. View