Rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2023 Aug 26

PMID 37628669

Authors

Giuseppina Rosaria Umano

Grazia Cirillo

Giulia Rondinelli

Gianmaria Sanchez

Pierluigi Marzuillo

Stefano Guarino

Anna Di Sessa

Alfonso Papparella

Emanuele Miraglia Del Giudice

Affiliations

Soon will be listed here.

Abstract

Childhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated with an increased risk of hypertension in adolescents. In this study, we aimed to investigate the effect of rs2254524 polymorphism on blood pressure in children and adolescents with obesity. We enrolled 828 obese children aged 6-17 years. Subjects carrying the A allele showed higher rates of systolic and diastolic stage I hypertension and stage II hypertension. Carriers of the A allele showed a 2.4-fold (95% C.I. 1.5-4.7, = 0.01) higher risk for stage II hypertension and a 1.9-fold higher risk for stage I hypertension (95% C.I. 1.4-2.6, < 0.0001). The risk was independent of confounding factors. In conclusion, rs2254524 worsens the cardiovascular health of children and adolescents with obesity, increasing their blood pressure.

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