Ameliorative Effects of L14 on Oxidative Stress and Gut Microbiota in Type 2 Diabetes Mellitus Rats

Overview

Journal Antioxidants (Basel)

Date 2023 Aug 26

PMID 37627510

Authors

Zhu Zeng

Yi Yang

Xinxin Zhong

Fangyin Dai

Shangwu Chen

Xiaoling Tong

Affiliations

Soon will be listed here.

Abstract

Bioprospecting of more novel probiotic strains has attained continuous interest. This study aimed to investigate the beneficial effects of strain L14, an isolate from a traditional Chinese dairy product, on type 2 diabetes mellitus (T2DM) rats. Preventive supplementation of strain L14 showed excellent anti-diabetic effects on high-fat diet/low-dose streptozotocin (HFD/STZ)-induced T2DM rats. It significantly reduced hyperglycemia, protected pancreatic β-cell and liver function, and ameliorated oxidative stress while considerably improving dyslipidemia and inflammation. Furthermore, the strain modulated the gut microbiota to alleviate gut dysbiosis. Interestingly, most of these biochemical parameters could even restore to normal levels by the intervention of strain L14. The whole-genome sequencing of L14 was performed to provide a critical molecular basis for its probiotic activities. Genes related to antioxidant systems and other beneficial microbial metabolites like exopolysaccharides (EPS) biosynthesis were found. This study demonstrates that probiotic L14 has good potential for applications in functional food and pharmaceutical industries.

Citing Articles

Elucidating the role of gut microbiota metabolites in diabetes by employing network pharmacology.

Yao W, Huo J, Ji J, Liu K, Tao P Mol Med. 2024; 30(1):263.

PMID: 39707185 PMC: 11660459. DOI: 10.1186/s10020-024-01033-0.

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