Evidence for a Non-precursor Dopamine Pool in Noradrenergic Neurones of the Dog Mesenteric Artery

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1986 Jul 1

PMID 3762736

Citations 11

Authors

P Soares-da-Silva

Affiliations

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Abstract

The effects of dopamine beta-hydroxylase inhibition by disulfiram on dopamine and noradrenaline concentrations were investigated at various times in the main trunk and proximal branches of the dog mesenteric artery. The effects of desmethylimipramine and benztropine on the uptake of exogenous dopamine in the proximal branches of the mesenteric artery were also analyzed. The rate constant of dopamine accumulation after dopamine beta-hydroxylase inhibition in the main trunk (0.1137 h-1) was significantly higher than that observed in the proximal branches (0.075 h-1). The rate constants of noradrenaline decline were similar in both segments of the mesenteric artery (about 0.052 h-1). The uptake of exogenous dopamine in the proximal branches of the mesenteric artery was insensitive to benztropine and only blocked by desmethylimipramine. These results suggest the existence of a non-precursor dopamine pool in noradrenergic neurones supplying the proximal branches of the dog mesenteric artery, and also provide evidence in favour of the absence of independent dopaminergic neurones in this vascular area.

Citing Articles

Cardiometabolic and Inflammatory Benefits of Sympathetic Down-Regulation with Zamicastat in Aged Spontaneously Hypertensive Rats.

Igreja B, Pires N, Loureiro A, Wright L, Soares-da-Silva P ACS Pharmacol Transl Sci. 2020; 2(5):353-360.

PMID: 32259069 PMC: 7089015. DOI: 10.1021/acsptsci.9b00039.

Antihypertensive effect of etamicastat in dopamine D2 receptor-deficient mice.

Armando I, Asico L, Wang X, Jones J, Serrao M, Cuevas S Hypertens Res. 2018; 41(7):489-498.

PMID: 29654295 PMC: 6503839. DOI: 10.1038/s41440-018-0041-5.

Blood pressure decrease in spontaneously hypertensive rats folowing renal denervation or dopamine β-hydroxylase inhibition with etamicastat.

Pires N, Igreja B, Moura E, Wright L, Serrao M, Soares-da-Silva P Hypertens Res. 2015; 38(9):605-12.

PMID: 25854989 DOI: 10.1038/hr.2015.50.

Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat.

Igreja B, Pires N, Bonifacio M, Loureiro A, Fernandes-Lopes C, Wright L Hypertens Res. 2014; 38(1):30-8.

PMID: 25298210 DOI: 10.1038/hr.2014.143.

Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-β-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects.

Nunes T, Rocha J, Vaz-da-Silva M, Igreja B, Wright L, Falcao A Drugs R D. 2010; 10(4):225-42.

PMID: 21171669 PMC: 3585840. DOI: 10.2165/11586310-000000000-00000.

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