Molecular Interactions Between Neuroglobin and Cytochrome Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2023 Aug 26

PMID 37627298

Authors

Marina A Semenova

Rita V Chertkova

Mikhail P Kirpichnikov

Dmitry A Dolgikh

Affiliations

Soon will be listed here.

Abstract

Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin and mitochondrial cytochrome may serve as at least one of the mechanisms of neuroglobin-mediated neuroprotection. Interestingly, neuroglobin and cytochrome possibly can interact with or without electron transfer both in the cytoplasm and within the mitochondria. This review provides a general picture of molecular interactions between neuroglobin and cytochrome based on the recent experimental and computational work on neuroglobin and cytochrome interactions.

Citing Articles

Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties.

Chertkova R, Oleynikov I, Pakhomov A, Sudakov R, Orlov V, Semenova M Cells. 2023; 12(18).

PMID: 37759538 PMC: 10528150. DOI: 10.3390/cells12182316.

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