S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2023 Aug 26

PMID 37627239

Authors

Angelo Mandarino

Swetha Thiyagarajan

Allana C F Martins

Roberto da Silva Gomes

Stefan W Vetter

Estelle Leclerc

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding proteins with diverse intra- and extracellular functions that modulate different aspects of tumorigenesis, including tumor growth and metastasis. High mobility group box 1 (HMGB1) protein is a multifaceted protein that also actively influences the development and progression of tumors. In this study, we investigate the possible correlations, at the transcript level, between S100s and HMGB1 in pancreatic cancer. For this purpose, we calculated Pearson's correlations between the transcript levels of 13 cancer-related S100 genes and HMGB1 in a cDNA array containing 19 pancreatic cancer tumor samples, and in 8 human pancreatic cancer cell lines. Statistically significant positive correlations were found in 5.5% (5 out of 91) and 37.4% (34 of 91) of the possible S100/S100 or S100/HMGB1 pairs in cells and tumors, respectively. Our data suggest that many S100 proteins crosstalk in pancreatic tumors either with other members of the S100 family, or with HMGB1. These newly observed interdependencies may be used to further the characterization of pancreatic tumors based on S100 and HMGB1 transcription profiles.

Citing Articles

Investigating underlying molecular mechanisms, signaling pathways, emerging therapeutic approaches in pancreatic cancer.

Mustafa M, Abbas K, Alam M, Habib S, Zulfareen , Hasan G Front Oncol. 2024; 14:1427802.

PMID: 39087024 PMC: 11288929. DOI: 10.3389/fonc.2024.1427802.

References

Kang R, Livesey K, Zeh H, Loze M, Tang D . HMGB1: a novel Beclin 1-binding protein active in autophagy. Autophagy. 2010; 6(8):1209-11. DOI: 10.4161/auto.6.8.13651. View

Cheng P, Ma Y, Gao Z, Duan L . High Mobility Group Box 1 (HMGB1) Predicts Invasion and Poor Prognosis of Glioblastoma Multiforme via Activating AKT Signaling in an Autocrine Pathway. Med Sci Monit. 2018; 24:8916-8924. PMC: 6296343. DOI: 10.12659/MSM.912104. View

Saul D, Kosinsky R, Atkinson E, Doolittle M, Zhang X, LeBrasseur N . A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022; 13(1):4827. PMC: 9381717. DOI: 10.1038/s41467-022-32552-1. View

Rescher U, Gerke V . S100A10/p11: family, friends and functions. Pflugers Arch. 2007; 455(4):575-82. DOI: 10.1007/s00424-007-0313-4. View

Zhang R, Fu H, Chen D, Hua J, Hu Y, Sun K . Subcellular distribution of S100A4 and its transcriptional regulation under hypoxic conditions in gastric cancer cell line BGC823. Cancer Sci. 2010; 101(5):1141-6. PMC: 11158214. DOI: 10.1111/j.1349-7006.2010.01533.x. View

Arumugam T, Simeone D, Schmidt A, Logsdon C . S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem. 2003; 279(7):5059-65. DOI: 10.1074/jbc.M310124200. View

Halbrook C, Lyssiotis C, Pasca di Magliano M, Maitra A . Pancreatic cancer: Advances and challenges. Cell. 2023; 186(8):1729-1754. PMC: 10182830. DOI: 10.1016/j.cell.2023.02.014. View

Iacobuzio-Donahue C, Maitra A, Olsen M, Lowe A, Van Heek N, Rosty C . Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol. 2003; 162(4):1151-62. PMC: 1851213. DOI: 10.1016/S0002-9440(10)63911-9. View

Ohuchida K, Mizumoto K, Miyasaka Y, Yu J, Cui L, Yamaguchi H . Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis. J Pathol. 2007; 213(3):275-82. DOI: 10.1002/path.2250. View

10.

Bresnick A, Weber D, Zimmer D . S100 proteins in cancer. Nat Rev Cancer. 2015; 15(2):96-109. PMC: 4369764. DOI: 10.1038/nrc3893. View

11.

Li H, Wang J, Jin X, Zhao L, Ye H, Kuang Y . Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma. BMC Cancer. 2021; 21(1):1039. PMC: 8447682. DOI: 10.1186/s12885-021-08769-6. View

12.

Sekine H, Chen N, Sato K, Saiki Y, Yoshino Y, Umetsu Y . S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells. Biochem Biophys Res Commun. 2012; 429(3-4):214-9. DOI: 10.1016/j.bbrc.2012.10.048. View

13.

Dakhel S, Padilla L, Adan J, Masa M, Martinez J, Roque L . S100P antibody-mediated therapy as a new promising strategy for the treatment of pancreatic cancer. Oncogenesis. 2014; 3:e92. PMC: 4038391. DOI: 10.1038/oncsis.2014.7. View

14.

Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika I, Youyi C . Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts. Oncol Res. 2019; 27(8):945-956. PMC: 7848232. DOI: 10.3727/096504019X15555408784978. View

15.

Shang S, Hua F, Hu Z . The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget. 2017; 8(20):33972-33989. PMC: 5464927. DOI: 10.18632/oncotarget.15687. View

16.

Pierce A, Barron N, Linehan R, Ryan E, ODriscoll L, Daly C . Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines. Eur J Cancer. 2007; 44(1):151-9. DOI: 10.1016/j.ejca.2007.10.017. View

17.

Leclerc E . Measuring binding of S100 proteins to RAGE by surface plasmon resonance. Methods Mol Biol. 2013; 963:201-13. DOI: 10.1007/978-1-62703-230-8_13. View

18.

Hu H, Zhang Q, Huang C, Shen Y, Chen X, Shi X . Diagnostic value of S100P for pancreatic cancer: a meta-analysis. Tumour Biol. 2014; 35(10):9479-85. DOI: 10.1007/s13277-014-2461-4. View

19.

Sun X, Wang T, Zhang C, Ning K, Guan Z, Chen S . S100A16 is a prognostic marker for colorectal cancer. J Surg Oncol. 2017; 117(2):275-283. DOI: 10.1002/jso.24822. View

20.

Chen H, Xu C, Jin Q, Liu Z . S100 protein family in human cancer. Am J Cancer Res. 2014; 4(2):89-115. PMC: 3960449. View