Structure, Sequence and Expression of the Hepatitis Delta (delta) Viral Genome

Overview

Journal Nature

Specialty Science

Date 1986 Oct 9

PMID 3762705

Citations 266

Authors

K S Wang

Q L Choo

A J Weiner

J H Ou

R C Najarian

R M Thayer

G T Mullenbach

K J Denniston

J L Gerin

M Houghton

Affiliations

Soon will be listed here.

Abstract

Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis delta viral infections.

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