Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease-Pathophysiology and Translational Therapeutic Approaches

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Aug 26

PMID 37626780

Authors

Michael Poledniczek

Christoph Neumayer

Christoph W Kopp

Oliver Schlager

Thomas Gremmel

Alicja Jozkowicz

Michael E Gschwandtner

Renate Koppensteiner

Patricia P Wadowski

Affiliations

Soon will be listed here.

Abstract

Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammatory pathways also contributing to pro-coagulability and a prothrombotic state. In addition, changes in the extracellular matrix composition lead to (peri-)vascular remodelling and alterations of the vessel wall, e.g., aneurysm formation. Moreover, progressive fibrosis leads to reduced tissue perfusion due to loss of functional capillaries. The present review aims at discussing the molecular and clinical effects of inflammatory processes on the micro- and macrovasculature with a focus on peripheral artery disease.

Citing Articles

Leukocyte Indices as Markers of Inflammation and Predictors of Outcome in Heart Failure with Preserved Ejection Fraction.

Poledniczek M, Kronberger C, List L, Gregshammer B, Willixhofer R, Ermolaev N J Clin Med. 2024; 13(19).

PMID: 39407935 PMC: 11477419. DOI: 10.3390/jcm13195875.

MicroRNAs regulate the vicious cycle of vascular calcification-osteoporosis in postmenopausal women.

Wang Q, Peng F, Yang J, Chen X, Peng Z, Zhang M Mol Biol Rep. 2024; 51(1):622.

PMID: 38709309 DOI: 10.1007/s11033-024-09550-1.

Translational Relevance of Advanced Age and Atherosclerosis in Preclinical Trials of Biotherapies for Peripheral Artery Disease.

Webster K Genes (Basel). 2024; 15(1).

PMID: 38275616 PMC: 10815340. DOI: 10.3390/genes15010135.

Myocardial Oedema as a Consequence of Viral Infection and Persistence-A Narrative Review with Focus on COVID-19 and Post COVID Sequelae.

Panagiotides N, Poledniczek M, Andreas M, Hulsmann M, Kocher A, Kopp C Viruses. 2024; 16(1).

PMID: 38257821 PMC: 10818479. DOI: 10.3390/v16010121.

Dynamic Perfusion Computed Tomography for the Assessment of Concomitant Coronary Artery Disease in Patients with a History of Percutaneous Transluminal Angioplasty for Chronic Limb-Threatening Ischemia-A Pilot Study.

Nagy F, Olajos D, Vattay B, Borzsak S, Boussoussou M, Deak M J Cardiovasc Dev Dis. 2023; 10(11).

PMID: 37998501 PMC: 10671941. DOI: 10.3390/jcdd10110443.

References

Hoisnard L, Pina Vegas L, Dray-Spira R, Weill A, Zureik M, Sbidian E . Risk of major adverse cardiovascular and venous thromboembolism events in patients with rheumatoid arthritis exposed to JAK inhibitors versus adalimumab: a nationwide cohort study. Ann Rheum Dis. 2022; 82(2):182-188. DOI: 10.1136/ard-2022-222824. View

Mahdavi Gorabi A, Kiaie N, Hajighasemi S, Banach M, Penson P, Jamialahmadi T . Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications. J Clin Med. 2019; 8(12). PMC: 6947613. DOI: 10.3390/jcm8122051. View

Jansen F, Yang X, Franklin B, Hoelscher M, Schmitz T, Bedorf J . High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovasc Res. 2013; 98(1):94-106. DOI: 10.1093/cvr/cvt013. View

de Leeuw K, Sanders J, Stegeman C, Smit A, Kallenberg C, Bijl M . Accelerated atherosclerosis in patients with Wegener's granulomatosis. Ann Rheum Dis. 2004; 64(5):753-9. PMC: 1755479. DOI: 10.1136/ard.2004.029033. View

Wang M, Zhang W, Zhang L, Wang L, Li J, Shu C . Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment. Biomed Res Int. 2021; 2021:9935671. PMC: 8337102. DOI: 10.1155/2021/9935671. View

Jager B, Piackova E, Haller P, Andric T, Kahl B, Christ G . Increased platelet reactivity in dyslipidemic patients with coronary artery disease on dual anti-platelet therapy. Arch Med Sci. 2019; 15(1):65-71. PMC: 6348363. DOI: 10.5114/aoms.2018.81035. View

Steiner S, Speidl W, Pleiner J, Seidinger D, Zorn G, Kaun C . Simvastatin blunts endotoxin-induced tissue factor in vivo. Circulation. 2005; 111(14):1841-6. DOI: 10.1161/01.CIR.0000158665.27783.0C. View

Almeida S, Budoff M . Effect of statins on atherosclerotic plaque. Trends Cardiovasc Med. 2019; 29(8):451-455. DOI: 10.1016/j.tcm.2019.01.001. View

Xu Y, An X, Guo X, Habtetsion T, Wang Y, Xu X . Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol. 2014; 34(6):1231-9. PMC: 4120754. DOI: 10.1161/ATVBAHA.113.303041. View

10.

Motoshima H, Wu X, Mahadev K, Goldstein B . Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun. 2004; 315(2):264-71. DOI: 10.1016/j.bbrc.2004.01.049. View

11.

Hou Y, Zheng C, Yen T, Lu K . Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection. Int J Mol Sci. 2020; 21(21). PMC: 7660105. DOI: 10.3390/ijms21217833. View

12.

Badacz R, Przewlocki T, Legutko J, Zmudka K, Kablak-Ziembicka A . microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective. Int J Mol Sci. 2022; 23(24). PMC: 9779323. DOI: 10.3390/ijms232415645. View

13.

Chen Y, Yuan H, Ou Z, Ou J . Microparticles (Exosomes) and Atherosclerosis. Curr Atheroscler Rep. 2020; 22(6):23. DOI: 10.1007/s11883-020-00841-z. View

14.

Brodsky S, Zhang F, Nasjletti A, Goligorsky M . Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol. 2004; 286(5):H1910-5. DOI: 10.1152/ajpheart.01172.2003. View

15.

Reis Geovanini G, Libby P . Atherosclerosis and inflammation: overview and updates. Clin Sci (Lond). 2018; 132(12):1243-1252. DOI: 10.1042/CS20180306. View

16.

Frank U, Nikol S, Belch J, Boc V, Brodmann M, Carpentier P . ESVM Guideline on peripheral arterial disease. Vasa. 2019; 48(Suppl 102):1-79. DOI: 10.1024/0301-1526/a000834. View

17.

Rout A, Tantry U, Novakovic M, Sukhi A, Gurbel P . Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction. Expert Opin Pharmacother. 2020; 21(15):1851-1865. DOI: 10.1080/14656566.2020.1787987. View

18.

Visseren F, Mach F, Smulders Y, Carballo D, Koskinas K, Back M . 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021; 42(34):3227-3337. DOI: 10.1093/eurheartj/ehab484. View

19.

Bays H, Ballantyne C, Braeckman R, Stirtan W, Soni P . Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies. Am J Cardiovasc Drugs. 2013; 13(1):37-46. PMC: 3572383. DOI: 10.1007/s40256-012-0002-3. View

20.

He J, Xiao Z, Chen X, Chen M, Fang L, Yang M . The expression of functional Toll-like receptor 4 is associated with proliferation and maintenance of stem cell phenotype in endothelial progenitor cells (EPCs). J Cell Biochem. 2010; 111(1):179-86. DOI: 10.1002/jcb.22686. View