Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Aug 26

PMID 37626640

Authors

Ioana Balinisteanu

Monica-Cristina Panzaru

Lavinia Caba

Maria-Christina Ungureanu

Andreea Florea

Ana Maria Grigore

Eusebiu Vlad Gorduza

Affiliations

Soon will be listed here.

Abstract

Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype-phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical).

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