Investigation into the Role of Long-Non-Coding RNA in Leukemia

Overview

Journal Noncoding RNA

Date 2023 Aug 25

PMID 37624039

Authors

Alessia Ostini

Mirna Mourtada-Maarabouni

Affiliations

Soon will be listed here.

Abstract

Myocardial Infarction Associated Transcript () is a nuclear long non-coding RNA (LncRNA) with four different splicing variants. dysregulation is associated with carcinogenesis, mainly acting as an oncogene regulating cellular growth, invasion, and metastasis. The aim of the current study is to investigate the role of in the regulation of T and chronic myeloid leukemic cell survival. To this end, was silenced using -specific siRNAs in leukemic cell lines, and functional assays were performed thereafter. This investigation also aims to investigate the effects of silencing on the expression of core genes involved in cancer. Functional studies and gene expression determination confirm that knockdown not only affects short- and long-term survival and the apoptosis of leukemic cells but also plays a pivotal role in the alteration of key genes involved in cancer, including and . Our observations suggest that could act as an oncogene and it has the potential to be used not only as a reliable biomarker for leukemia, but also be employed for prognostic and therapeutic purposes.

Citing Articles

Recent advances on biogenesis, functions and therapeutic potential of long noncoding RNAs in T cell acute lymphoblastic leukemia.

Kaur P, Sharma P, Bhatia P, Singh M Discov Oncol. 2024; 15(1):729.

PMID: 39612075 PMC: 11607202. DOI: 10.1007/s12672-024-01618-5.

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