Relationship Between Sedentary Behavior and Endothelial Dysfunction in a Cross-sectional Study in China

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2023 Aug 25

PMID 37621562

Authors

Ping-Ting Yang

Sai-Qi Yang

Yong-Mei He

Jian-Gang Wang

Yue-Xiang Qin

Ya-Qin Wang

Ying Li

Affiliations

Soon will be listed here.

Abstract

Methods: We recruited 13,220 participants from two health management centers of general tertiary hospitals located in northern and southern China between 2017 and 2021. All participants had undergone both questionnaires and brachial artery flow-mediated dilation (FMD) measurements.

Results: In total, 3,205 participants with FMD ≤ 5.0% were identified to have endothelial dysfunction. In a multivariable regression model including lifestyle habits such as sedentary behavior and cardiovascular risk factors, taking leisure sedentary time <2 h/day as a reference, the risk of vascular endothelial dysfunction gradually increased with time: 2-4 h/day (OR= 1.182, 95% CI: 1.058-1.321, = 0.003), 4-6 h/day (OR= 1.248, 95% CI: 1.100-1.414, = 0.001) and >6 h/day (OR= 1.618, 95% CI: 1.403-1.866, < 0.001).

Conclusion: Longer leisure sedentary time is associated with a higher prevalence of vascular endothelial dysfunction. These findings suggest that leisure sedentary behavior is a risk factor for the occurrence of vascular endothelial dysfunction in the Chinese check-up population.

References

Gilchrist S, Howard V, Akinyemiju T, Judd S, Cushman M, Hooker S . Association of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults. JAMA Oncol. 2020; 6(8):1210-1217. PMC: 7303924. DOI: 10.1001/jamaoncol.2020.2045. View

Shechter M, Shechter A, Koren-Morag N, Feinberg M, Hiersch L . Usefulness of brachial artery flow-mediated dilation to predict long-term cardiovascular events in subjects without heart disease. Am J Cardiol. 2013; 113(1):162-7. DOI: 10.1016/j.amjcard.2013.08.051. View

. [2016 Chinese guideline for the management of dyslipidemia in adults]. Zhonghua Xin Xue Guan Bing Za Zhi. 2016; 44(10):833-853. DOI: 10.3760/cma.j.issn.0253-3758.2016.10.005. View

Joundi R, Patten S, Williams J, Smith E . Association Between Excess Leisure Sedentary Time and Risk of Stroke in Young Individuals. Stroke. 2021; 52(11):3562-3568. DOI: 10.1161/STROKEAHA.121.034985. View

Yoshida T, Kawano H, Miyamoto S, Motoyama T, Fukushima H, Hirai N . Prognostic value of flow-mediated dilation of the brachial artery in patients with cardiovascular disease. Intern Med. 2006; 45(9):575-9. DOI: 10.2169/internalmedicine.45.1534. View

Yang P, Li Y, Wang J, Zhang L, Yang S, Tang L . The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China. J Atheroscler Thromb. 2022; 30(6):684-697. PMC: 10244076. DOI: 10.5551/jat.63695. View

Hallal P, Andersen L, Bull F, Guthold R, Haskell W, Ekelund U . Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet. 2012; 380(9838):247-57. DOI: 10.1016/S0140-6736(12)60646-1. View

Jambrik Z, Venneri L, Varga A, Rigo F, Borges A, Picano E . Peripheral vascular endothelial function testing for the diagnosis of coronary artery disease. Am Heart J. 2004; 148(4):684-9. DOI: 10.1016/j.ahj.2004.04.016. View

Xu Z, Xu Q, Wang Y, Zhang J, Liu J, Xu F . Association of Sedentary Behavior and Depression among College Students Majoring in Design. Int J Environ Res Public Health. 2020; 17(10). PMC: 7277344. DOI: 10.3390/ijerph17103545. View

10.

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C . 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2019; 41(3):407-477. DOI: 10.1093/eurheartj/ehz425. View

11.

Bauman A, Ainsworth B, Sallis J, Hagstromer M, Craig C, Bull F . The descriptive epidemiology of sitting. A 20-country comparison using the International Physical Activity Questionnaire (IPAQ). Am J Prev Med. 2011; 41(2):228-35. DOI: 10.1016/j.amepre.2011.05.003. View

12.

Duran A, Pascual C, Goldsmith J, Howard V, Hutto B, Colabianchi N . Objectively Measured Physical Activity and Sedentary Time Among Adults With and Without Stroke: A National Cohort Study. Stroke. 2021; 52(11):e729-e732. DOI: 10.1161/STROKEAHA.121.034194. View

13.

Diaz K, Howard V, Hutto B, Colabianchi N, Vena J, Safford M . Patterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults: A National Cohort Study. Ann Intern Med. 2017; 167(7):465-475. PMC: 5961729. DOI: 10.7326/M17-0212. View

14.

Bowden Davies K, Norman J, Thompson A, Mitchell K, Harrold J, Halford J . Short-Term Physical Inactivity Induces Endothelial Dysfunction. Front Physiol. 2021; 12:659834. PMC: 8064120. DOI: 10.3389/fphys.2021.659834. View

15.

Cao Z, Xu C, Zhang P, Wang Y . Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model. EClinicalMedicine. 2022; 48:101424. PMC: 9065298. DOI: 10.1016/j.eclinm.2022.101424. View

16.

Tang J, Liu K, Eshak E, Cui R, Sakaniwa R, Imano H . Association between Serum Uric Acid and Impaired Endothelial Function: The Circulatory Risk in Communities Study. J Atheroscler Thromb. 2021; 29(10):1534-1546. PMC: 9529376. DOI: 10.5551/jat.63199. View

17.

Koolhaas C, Dhana K, van Rooij F, Kocevska D, Hofman A, Franco O . Sedentary time assessed by actigraphy and mortality: The Rotterdam Study. Prev Med. 2016; 95:59-65. DOI: 10.1016/j.ypmed.2016.11.021. View

18.

Duran A, Romero E, Diaz K . Is Sedentary Behavior a Novel Risk Factor for Cardiovascular Disease?. Curr Cardiol Rep. 2022; 24(4):393-403. DOI: 10.1007/s11886-022-01657-w. View

19.

Toyoda S, Tokoi S, Takekawa H, Matsumoto H, Inami S, Sakuma M . Relationship between brachial flow-mediated dilation and carotid intima-media thickness in patients with coronary artery disease. Int Angiol. 2020; 39(5):433-442. DOI: 10.23736/S0392-9590.20.04315-1. View

20.

Taylor F, Pinto A, Maniar N, Dunstan D, Green D . The Acute Effects of Prolonged Uninterrupted Sitting on Vascular Function: A Systematic Review and Meta-analysis. Med Sci Sports Exerc. 2021; 54(1):67-76. DOI: 10.1249/MSS.0000000000002763. View