Diffuse LAD and LV Thrombus As Possible Manifestation of Protein-S Deficiency in a Young Patient

Overview

Journal JACC Case Rep

Specialty Cardiology & Vascular Diseases

Date 2023 Aug 24

PMID 37614329

Authors

Konstantinos Kalogeras

Stella-Maria Kyvelou

Nikolaos Vythoulkas-Biotis

Theodoros Pesiridis

Georgia Vogiatzi

Efstratios Katsianos

Michael Andrew Vavuranakis

Evangelos Oikonomou

Gerasimos Siasos

Manolis Vavuranakis

Affiliations

Soon will be listed here.

Abstract

Patients with inherited hypercoagulopathies such as protein-S deficiency commonly present with venous thrombosis. However, there are rare cases of arterial thrombosis. We describe a rare case of a diffuse left anterior descending and left ventricular thrombus in a young patient with protein-S deficiency complicated with mid cerebral artery occlusion. ().

Citing Articles

Hereditary Protein S Deficiency With an Extensive Femoral Artery Thrombosis.

Noor N, Che Anuar N, Saidin N, Iberahim S, Hanan Abdullah A Cureus. 2024; 15(12):e51355.

PMID: 38292964 PMC: 10825390. DOI: 10.7759/cureus.51355.

Testing for Hypercoagulability in Patients With Unexplained Arterial Thromboembolism.

Chan N, Eikelboom J JACC Case Rep. 2023; 20:101944.

PMID: 37614328 PMC: 10442601. DOI: 10.1016/j.jaccas.2023.101944.

References

Ibanez B, James S, Agewall S, Antunes M, Bucciarelli-Ducci C, Bueno H . 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European.... Eur Heart J. 2017; 39(2):119-177. DOI: 10.1093/eurheartj/ehx393. View

Chandrasekaran B, Kurbaan A . Myocardial infarction with angiographically normal coronary arteries. J R Soc Med. 2002; 95(8):398-400. PMC: 1279964. DOI: 10.1258/jrsm.95.8.398. View

Soare A, Popa C . Deficiencies of proteins C, S and antithrombin and activated protein C resistance--their involvement in the occurrence of Arterial thromboses. J Med Life. 2011; 3(4):412-5. PMC: 3019073. View

Boekholdt S, Kramer M . Arterial thrombosis and the role of thrombophilia. Semin Thromb Hemost. 2007; 33(6):588-96. DOI: 10.1055/s-2007-985755. View

Rudnicka A, Miller G, Nelson T, Doray D, Comp P . An association between plasma free protein s concentration and risk of coronary heart disease in middle-aged men. Thromb Res. 2001; 101(2):1-11. DOI: 10.1016/s0049-3848(00)00379-0. View

Sayin M, Akpinar I, Karabag T, Aydin M, Dogan S, Cil C . Left main coronary artery thrombus resulting from combined protein C and S deficiency. Intern Med. 2012; 51(21):3041-4. DOI: 10.2169/internalmedicine.51.8341. View

Beattie S, Norton M, Doll D . Coronary thrombosis associated with inherited protein S deficiency: a case report. Heart Lung. 1997; 26(1):76-9. DOI: 10.1016/s0147-9563(97)90012-1. View

Anderson J, Weitz J . Hypercoagulable states. Crit Care Clin. 2011; 27(4):933-52, vii. DOI: 10.1016/j.ccc.2011.09.007. View

Middeldorp S, Prins M, Buller H . [No indication for thrombophilia screening in patients with idiopathic venous thromboembolism and their relatives]. Ned Tijdschr Geneeskd. 2001; 145(22):1047-51. View

10.

Segev A, Ellis M, Segev F, Friedman Z, Reshef T, Sparkes J . High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors. Int J Cardiol. 2005; 98(3):421-4. DOI: 10.1016/j.ijcard.2003.10.057. View

11.

Rallidis L, Belesi C, Manioudaki H, Chatziioakimidis V, Fakitsa V, Sinos L . Myocardial infarction under the age of 36: prevalence of thrombophilic disorders. Thromb Haemost. 2003; 90(2):272-8. DOI: 10.1160/TH02-11-0286. View

12.

Ten Kate M, van der Meer J . Protein S deficiency: a clinical perspective. Haemophilia. 2008; 14(6):1222-8. DOI: 10.1111/j.1365-2516.2008.01775.x. View