Plasma MiR-195-5p Predicts the Severity of Covid-19 in Hospitalized Patients

Overview

Journal Sci Rep

Specialty Science

Date 2023 Aug 23

PMID 37612439

Authors

Alexandra Ioana Moatar

Aimee Rodica Chis

Mirabela Romanescu

Paula-Diana Ciordas

Diana Nitusca

Catalin Marian

Cristian Oancea

Ioan-Ovidiu Sirbu

Affiliations

Soon will be listed here.

Abstract

Predicting the clinical course of Covid-19 is a challenging task, given the multi-systemic character of the disease and the paucity of minimally invasive biomarkers of disease severity. Here, we evaluated the early (first two days post-admission) level of circulating hsa-miR-195-5p (miR-195, a known responder to viral infections and SARS-CoV-2 interactor) in Covid-19 patients and assessed its potential as a biomarker of disease severity. We show that plasma miR-195 correlates with several clinical and paraclinical parameters, and is an excellent discriminator between the severe and mild forms of the disease. Our Gene Ontology analysis of miR-195 targets differentially expressed in Covid-19 indicates a strong impact on cardiac mitochondria homeostasis, suggesting a possible role in long Covid and chronic fatigue syndrome (CFS) syndromes.

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