Dose-dependent Impact of Human Milk Feeding on Tidal Breathing Flow-volume Loop Parameters Across the First 2 Years of Life in Extremely Low-birth-weight Infants: a Cohort Study

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2023 Aug 23

PMID 37610435

Authors

Anna Lavizzari

Benedetta Esposito

Nicola Pesenti

Alina Shaykhova

Giulia Vizzari

Marijke Ophorst

Silvana Gangi

Daniela Morniroli

Mariarosa Colnaghi

Fabio Mosca

Maria L Gianni

Affiliations

Soon will be listed here.

Abstract

Conclusion: Preterm infants with higher consumption of HM had significantly less airway obstruction across the first 2 years, suggesting that human milk may contribute in a dose-dependent manner to improve lung function in early childhood in former preterm infants born ELBW.

What Is Known: • Human milk feeding reduces the risk of prematurity-related morbidities, including necrotizing enterocolitis, sepsis, lower respiratory tract infections, and BPD. Both exclusive and partial human milk feeding appear to be associated with a lower risk of BPD in preterm infants.

What Is New: • This cohort study of 180 preterm infants with birth weight < 1000 g found that exposure to human milk during hospitalization improves airway obstruction markers tPTEF/tE z-score over the first 2 years of corrected age in a dose-dependent manner.

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