Quantitative Estimation of Phospholipid Molecules Desorbed from a Microbubble Surface Under Ultrasound Irradiation

Overview

Journal Sci Rep

Specialty Science

Date 2023 Aug 22

PMID 37608058

Authors

Reina Kobayashi

Jun Narita

Natsumi Nakaoka

Marie Pierre Krafft

Daisuke Koyama

Affiliations

Soon will be listed here.

Abstract

Microbubbles have potential applications as drug and gene carriers, and drug release can be triggered by externally applied ultrasound irradiation while inside blood vessels. Desorption of molecules forming the microbubble shell can be observed under ultrasound irradiation of a single isolated microbubble, and the volume of desorbed molecules can be quantitatively estimated from the contact angle between the bubble and a glass plate. Microbubbles composed of a 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) shell and a poorly-soluble gas are created. When the microbubbles are exposed to a pulsed ultrasound, the contact angles increase dramatically; the percentage of DMPC molecules desorbed from the bubble surface reaches 70%. Vibration of a single bubble in the radial direction is measured using a laser Doppler vibrometer. The relationship between the vibrational characteristics and the amount of molecular desorption reveals that a larger vibrational amplitude of the bubble around the resonance size induces a larger amount of molecular desorption. These results support the possibility of controlling molecular desorption with pulsed ultrasound.

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