The Function of Exosomes in Ovarian Granulosa Cells

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 2023 Aug 21

PMID 37603064

Authors

Ruotong Zhou

Dan Liu

Affiliations

Soon will be listed here.

Abstract

Granulosa cells (GCs), as the basic components of ovarian tissue, play an indispensable role in maintaining normal ovarian functions such as hormone synthesis and ovulation. The abnormality of GCs often leads to ovarian endocrine disorders, which exert a negative effect on life quality and life expectancy. However, the pathogenesis and treatment of diseases are still poorly understood. Exosomes contain regulatory molecules and can transmit biological information in cell interaction. The role of exosomes in GCs has been studied extensively. This review summarizes the regulatory function of exosomes in GCs, as well as their participation in etiopathogenesis and their promising application in treatment when it comes to ovarian endocrine diseases, which can help us better understand ovarian diseases from the perspective of GCs.

Citing Articles

Menstrual Blood Stem Cells-Derived Exosomes as Promising Therapeutic Tools in Premature Ovarian Insufficiency Induced by Gonadotoxic Systemic Anticancer Treatment.

Cordeiro M, Roque R, Laranjeiro B, Carvalhos C, Figueiredo-Dias M Int J Mol Sci. 2024; 25(15).

PMID: 39126037 PMC: 11312895. DOI: 10.3390/ijms25158468.

References

Buccione R, Schroeder A, Eppig J . Interactions between somatic cells and germ cells throughout mammalian oogenesis. Biol Reprod. 1990; 43(4):543-7. DOI: 10.1095/biolreprod43.4.543. View

Cao J, Huo P, Cui K, Wei H, Cao J, Wang J . Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome. Cell Commun Signal. 2022; 20(1):61. PMC: 9082924. DOI: 10.1186/s12964-022-00876-6. View

Chen S, Wang Y, Liao L, Meng L, Li J, Shi C . Similar Repair Effects of Human Placenta, Bone Marrow Mesenchymal Stem Cells, and Their Exosomes for Damaged SVOG Ovarian Granulosa Cells. Stem Cells Int. 2020; 2020:8861557. PMC: 7738794. DOI: 10.1155/2020/8861557. View

Dehghan Z, Mohammadi-Yeganeh S, Rezaee D, Salehi M . MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development. Dev Biol. 2021; 480:69-77. DOI: 10.1016/j.ydbio.2021.08.008. View

Dewailly D, Robin G, Peigne M, Decanter C, Pigny P, Catteau-Jonard S . Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Hum Reprod Update. 2016; 22(6):709-724. DOI: 10.1093/humupd/dmw027. View

Di Y, Han X, Kang X, Wang D, Chen C, Wang J . Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis. Autophagy. 2020; 17(5):1170-1192. PMC: 8143247. DOI: 10.1080/15548627.2020.1752497. View

Ding C, Qian C, Hou S, Lu J, Zou Q, Li H . Exosomal miRNA-320a Is Released from hAMSCs and Regulates SIRT4 to Prevent Reactive Oxygen Species Generation in POI. Mol Ther Nucleic Acids. 2020; 21:37-50. PMC: 7272510. DOI: 10.1016/j.omtn.2020.05.013. View

Ding C, Zhu L, Shen H, Lu J, Zou Q, Huang C . Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7. Stem Cells. 2020; 38(9):1137-1148. DOI: 10.1002/stem.3204. View

Ding L, Gao F, Zhang M, Yan W, Tang R, Zhang C . Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome. Fertil Steril. 2016; 105(5):1330-1337.e3. DOI: 10.1016/j.fertnstert.2016.01.020. View

10.

Escobar-Morreale H . Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018; 14(5):270-284. DOI: 10.1038/nrendo.2018.24. View

11.

Hu J, Tang T, Zeng Z, Wu J, Tan X, Yan J . The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome. PeerJ. 2020; 8:e8640. PMC: 7035867. DOI: 10.7717/peerj.8640. View

12.

Huang B, Lu J, Ding C, Zou Q, Wang W, Li H . Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD. Stem Cell Res Ther. 2018; 9(1):216. PMC: 6085638. DOI: 10.1186/s13287-018-0953-7. View

13.

Hung W, Hong X, Christenson L, McGinnis L . Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion. Biol Reprod. 2015; 93(5):117. PMC: 4712005. DOI: 10.1095/biolreprod.115.132977. View

14.

Hung W, Navakanitworakul R, Khan T, Zhang P, Davis J, McGinnis L . Stage-specific follicular extracellular vesicle uptake and regulation of bovine granulosa cell proliferation. Biol Reprod. 2017; 97(4):644-655. PMC: 6248580. DOI: 10.1093/biolre/iox106. View

15.

Jeelani R, Khan S, Shaeib F, Kohan-Ghadr H, Aldhaheri S, Najafi T . Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality. Free Radic Biol Med. 2017; 110:11-18. PMC: 6854673. DOI: 10.1016/j.freeradbiomed.2017.05.006. View

16.

Kowalczyk A, Wrzecinska M, Czerniawska-Piatkowska E, Kupczynski R . Exosomes - Spectacular role in reproduction. Biomed Pharmacother. 2022; 148:112752. DOI: 10.1016/j.biopha.2022.112752. View

17.

Lee S, Oh H, Kim M, Lee B . Canine oviductal exosomes improve oocyte development via EGFR/MAPK signaling pathway. Reproduction. 2020; 160(4):613-625. DOI: 10.1530/REP-19-0600. View

18.

Lee S, Oh H, Kim M, Lee B . Exosomes derived from oviduct cells mediate the EGFR/MAPK signaling pathway in cumulus cells. J Cell Physiol. 2019; 235(2):1386-1404. DOI: 10.1002/jcp.29058. View

19.

Li H, Huang X, Chang X, Yao J, He Q, Shen Z . S100-A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF-κB pathway in polycystic ovary syndrome. J Cell Mol Med. 2019; 24(1):114-125. PMC: 6933366. DOI: 10.1111/jcmm.14642. View

20.

Liu K, Yang W, Hu M, Xie W, Huang J, Cui M . Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS. J Cell Mol Med. 2021; 25(8):3976-3990. PMC: 8051746. DOI: 10.1111/jcmm.16355. View