The Interplay Between H3K36 Methylation and DNA Methylation in Cancer

Overview

Journal Cancer Biol Med

Specialty Oncology

Date 2023 Aug 21

PMID 37602556

Authors

Jiameng Dan

Zeling Du

Jinghong Zhang

Taiping Chen

Affiliations

Soon will be listed here.

References

Sheng W, LaFleur M, Nguyen T, Chen S, Chakravarthy A, Conway J . LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell. 2018; 174(3):549-563.e19. PMC: 6063761. DOI: 10.1016/j.cell.2018.05.052. View

Schmitges F, Prusty A, Faty M, Stutzer A, Lingaraju G, Aiwazian J . Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell. 2011; 42(3):330-41. DOI: 10.1016/j.molcel.2011.03.025. View

Aytes A, Giacobbe A, Mitrofanova A, Ruggero K, Cyrta J, Arriaga J . NSD2 is a conserved driver of metastatic prostate cancer progression. Nat Commun. 2018; 9(1):5201. PMC: 6281610. DOI: 10.1038/s41467-018-07511-4. View

Sun Z, Lin Y, Islam M, Koche R, Hedehus L, Liu D . Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1. Mol Cell. 2023; 83(14):2398-2416.e12. PMC: 10529604. DOI: 10.1016/j.molcel.2023.06.007. View

Wu G, Broniscer A, McEachron T, Lu C, Paugh B, Becksfort J . Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012; 44(3):251-3. PMC: 3288377. DOI: 10.1038/ng.1102. View

Meng F, Sun G, Zhong M, Yu Y, Brewer M . Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. Br J Cancer. 2013; 108(3):579-86. PMC: 3593556. DOI: 10.1038/bjc.2013.10. View

Zhuang L, Jang Y, Park Y, Lee J, Jain S, Froimchuk E . Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018; 9(1):1796. PMC: 5935725. DOI: 10.1038/s41467-018-04127-6. View

Chen Q, Liu B, Zeng Y, Hwang J, Dai N, Correa Jr I . GSK-3484862 targets DNMT1 for degradation in cells. NAR Cancer. 2023; 5(2):zcad022. PMC: 10189803. DOI: 10.1093/narcan/zcad022. View

Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen S . DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell. 2015; 162(5):961-73. PMC: 4843502. DOI: 10.1016/j.cell.2015.07.056. View

10.

Kurotaki N, Imaizumi K, Harada N, Masuno M, Kondoh T, Nagai T . Haploinsufficiency of NSD1 causes Sotos syndrome. Nat Genet. 2002; 30(4):365-6. DOI: 10.1038/ng863. View

11.

Audia J, Campbell R . Histone Modifications and Cancer. Cold Spring Harb Perspect Biol. 2016; 8(4):a019521. PMC: 4817802. DOI: 10.1101/cshperspect.a019521. View

12.

Shirane K, Miura F, Ito T, Lorincz M . NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing. Nat Genet. 2020; 52(10):1088-1098. DOI: 10.1038/s41588-020-0689-z. View

13.

Fahey C, Davis I . SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation. Cold Spring Harb Perspect Med. 2017; 7(5). PMC: 5411680. DOI: 10.1101/cshperspect.a026468. View

14.

Li Y, Goldberg E, Chen X, Xu X, McGuire J, Leuzzi G . Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Mol Cell. 2022; 82(20):3901-3918.e7. PMC: 9588679. DOI: 10.1016/j.molcel.2022.09.007. View

15.

. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-82. PMC: 4311405. DOI: 10.1038/nature14129. View

16.

Pappalardi M, Keenan K, Cockerill M, Kellner W, Stowell A, Sherk C . Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021; 2(10):1002-1017. PMC: 8594913. View

17.

Wu Q, Nie D, Ba-Alawi W, Ji Y, Zhang Z, Cruickshank J . PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nat Chem Biol. 2022; 18(8):821-830. PMC: 9337992. DOI: 10.1038/s41589-022-01024-4. View

18.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

19.

Tatton-Brown K, Seal S, Ruark E, Harmer J, Ramsay E, Del Vecchio Duarte S . Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability. Nat Genet. 2014; 46(4):385-8. PMC: 3981653. DOI: 10.1038/ng.2917. View

20.

Kim S, Zhao H, Hardikar S, Singh A, Goodell M, Chen T . A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013; 122(25):4086-9. PMC: 3952368. DOI: 10.1182/blood-2013-02-483487. View