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Synthesis, Crystal Structure and Hirshfeld Surface Analysis of Bis-(caffeinium) Hexa-chlorido-platinum(IV) in Comparison with Some Related Compounds

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Abstract

The mol-ecular and crystal structure of the title compound, (CHNO)[PtCl], synthesized from hexa-chloro-platinic acid and caffeine in methanol, was studied by single-crystal X-ray diffraction. The caffeinium cations form a double layer hydrogen bonds and π-stacking inter-actions. The Hirshfeld surface analysis showed that the largest contribution to the crystal packing is made by H⋯H (31.2%), H⋯Cl/Cl⋯H (22.6%), O⋯H/H⋯O (21.9%) contacts for the cation and H⋯Cl/Cl⋯H (79.3%) contacts for the anion.

References
1.
Santos C, Costa J, Santos J, Vaz-Carneiro A, Lunet N . Caffeine intake and dementia: systematic review and meta-analysis. J Alzheimers Dis. 2010; 20 Suppl 1:S187-204. DOI: 10.3233/JAD-2010-091387. View

2.
Knapik J, Steelman R, Trone D, Farina E, Lieberman H . Prevalence of caffeine consumers, daily caffeine consumption, and factors associated with caffeine use among active duty United States military personnel. Nutr J. 2022; 21(1):22. PMC: 9008906. DOI: 10.1186/s12937-022-00774-0. View

3.
Lucas X, Bauza A, Frontera A, Quinonero D . A thorough anion-π interaction study in biomolecules: on the importance of cooperativity effects. Chem Sci. 2018; 7(2):1038-1050. PMC: 5967298. DOI: 10.1039/c5sc01386k. View

4.
Blaser H, Studer M . Cinchona-modified platinum catalysts: from ligand acceleration to technical processes. Acc Chem Res. 2007; 40(12):1348-56. DOI: 10.1021/ar700088f. View

5.
Dilruba S, Kalayda G . Platinum-based drugs: past, present and future. Cancer Chemother Pharmacol. 2016; 77(6):1103-24. DOI: 10.1007/s00280-016-2976-z. View