Does Air Pollution Exposure Affect Semen Quality? Evidence from a Systematic Review and Meta-analysis of 93,996 Chinese Men

Overview

Journal Front Public Health

Specialty Public Health

Date 2023 Aug 21

PMID 37601219

Authors

Junjie Liu

Yanpeng Dai

Runqing Li

Jiayi Yuan

Quanxian Wang

Linkai Wang

Affiliations

Soon will be listed here.

Abstract

Background: Air pollution may impair male fertility, but it remains controversial whether air pollution affects semen quality until now.

Objectives: We undertake a meta-analysis to explore potential impacts of six pollutants exposure during the entire window (0-90 days prior to ejaculation) and critical windows (0-9, 10-14, and 70-90 days prior to ejaculation) on semen quality.

Methods: Seven databases were retrieved for original studies on the effects of six pollutants exposure for 90 days prior to ejaculation on semen quality. The search process does not limit the language and search date. We only included original studies that reported regression coefficients () with 95% confidence intervals (CIs). The and 95% CIs were pooled using the DerSimonian-Laird random effect models.

Results: PM exposure was related with decreased total sperm number (10-14 lag days) and total motility (10-14, 70-90, and 0-90 lag days). PM exposure was related with reduced total sperm number (70-90 and 0-90 lag days) and total motility (0-90 lag days). NO exposure was related with reduced total sperm number (70-90 and 0-90 lag days). SO exposure was related with declined total motility (0-9, 10-14, 0-90 lag days) and total sperm number (0-90 lag days).

Conclusion: Air pollution affects semen quality making it necessary to limit exposure to air pollution for Chinese men. When implementing protective measures, it is necessary to consider the key period of sperm development.

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References

Cao W, Wang X, Li J, Yan M, Chang C, Kim J . NLRP3 inflammasome activation determines the fibrogenic potential of PM air pollution particles in the lung. J Environ Sci (China). 2021; 111:429-441. DOI: 10.1016/j.jes.2021.04.021. View

Kelly F . Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med. 2003; 60(8):612-6. PMC: 1740593. DOI: 10.1136/oem.60.8.612. View

Dai X, Chen G, Zhang M, Mei K, Liu Y, Ding C . Exposure to ambient particulate matter affects semen quality: A case study in Wenzhou, China. Andrology. 2022; 11(3):444-455. DOI: 10.1111/andr.13326. View

Wang X, Yang X, Xu H, Cao P, Gao P, Liang J . [Exposure status and health risk assessment of deoxynivalenol from cereals in Chinese population in different regions]. Zhonghua Yu Fang Yi Xue Za Zhi. 2019; 53(4):394-397. DOI: 10.3760/cma.j.issn.0253-9624.2019.04.012. View

Liu L, Yang X, Liu H, Wang M, Welles S, Marquez S . Spatial-Temporal Analysis of Air Pollution, Climate Change, and Total Mortality in 120 Cities of China, 2012-2013. Front Public Health. 2016; 4:143. PMC: 4947578. DOI: 10.3389/fpubh.2016.00143. View

Guyatt G, Oxman A, Kunz R, Brozek J, Alonso-Coello P, Rind D . GRADE guidelines 6. Rating the quality of evidence--imprecision. J Clin Epidemiol. 2011; 64(12):1283-93. DOI: 10.1016/j.jclinepi.2011.01.012. View

Krzastek S, Farhi J, Gray M, Smith R . Impact of environmental toxin exposure on male fertility potential. Transl Androl Urol. 2021; 9(6):2797-2813. PMC: 7807371. DOI: 10.21037/tau-20-685. View

Tian X, Wang X, Ye B, Li C, Zhang Y, Ma L . [The effects of exposure to ozone on sperm quality in Wuhan]. Zhonghua Yu Fang Yi Xue Za Zhi. 2017; 51(3):197-202. DOI: 10.3760/cma.j.issn.0253-9624.2017.03.002. View

Liu Y, Zhou Y, Ma J, Bao W, Li J, Zhou T . Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China. Environ Sci Technol. 2017; 51(21):12806-12814. PMC: 5822717. DOI: 10.1021/acs.est.7b03289. View

10.

Zhang F, Li H, Xu W, Song G, Wang Z, Mao X . Sulfur dioxide may predominate in the adverse effects of ambient air pollutants on semen quality among the general population in Hefei, China. Sci Total Environ. 2023; 867:161472. DOI: 10.1016/j.scitotenv.2023.161472. View

11.

Tang H, Zhang S, Chen W . Assessing Representative CCUS Layouts for China's Power Sector toward Carbon Neutrality. Environ Sci Technol. 2021; 55(16):11225-11235. DOI: 10.1021/acs.est.1c03401. View

12.

Zhou N, Jiang C, Chen Q, Yang H, Wang X, Zou P . Exposures to Atmospheric PM and PM Affect Male Semen Quality: Results of MARHCS Study. Environ Sci Technol. 2018; 52(3):1571-1581. DOI: 10.1021/acs.est.7b05206. View

13.

Zhou L, Li L, Hao G, Li B, Yang S, Wang N . Sperm mtDNA copy number, telomere length, and seminal spermatogenic cells in relation to ambient air pollution: Results of a cross-sectional study in Jing-Jin-Ji region of China. J Hazard Mater. 2020; 406:124308. DOI: 10.1016/j.jhazmat.2020.124308. View

14.

Takeshima T, Yumura Y, Yasuda K, Sanjo H, Kuroda S, Yamanaka H . Inverse correlation between reactive oxygen species in unwashed semen and sperm motion parameters as measured by a computer-assisted semen analyzer. Asian J Androl. 2016; 19(3):350-354. PMC: 5427793. DOI: 10.4103/1008-682X.173933. View

15.

Franklin B, Brook R, Pope 3rd C . Air pollution and cardiovascular disease. Curr Probl Cardiol. 2015; 40(5):207-38. DOI: 10.1016/j.cpcardiol.2015.01.003. View

16.

Zeng Y, Cao Y, Qiao X, Seyler B, Tang Y . Air pollution reduction in China: Recent success but great challenge for the future. Sci Total Environ. 2019; 663:329-337. DOI: 10.1016/j.scitotenv.2019.01.262. View

17.

Dutta A, Jinsart W . Air pollution in Delhi, India: It's status and association with respiratory diseases. PLoS One. 2022; 17(9):e0274444. PMC: 9488831. DOI: 10.1371/journal.pone.0274444. View

18.

Balshem H, Helfand M, Schunemann H, Oxman A, Kunz R, Brozek J . GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011; 64(4):401-6. DOI: 10.1016/j.jclinepi.2010.07.015. View

19.

Fathi Najafi T, Latifnejad Roudsari R, Namvar F, Ghavami Ghanbarabadi V, Hadizadeh Talasaz Z, Esmaeli M . Air pollution and quality of sperm: a meta-analysis. Iran Red Crescent Med J. 2015; 17(4):e26930. PMC: 4443398. DOI: 10.5812/ircmj.17(4)2015.26930. View

20.

Lao X, Zhang Z, Lau A, Chan T, Chuang Y, Chan J . Exposure to ambient fine particulate matter and semen quality in Taiwan. Occup Environ Med. 2017; 75(2):148-154. PMC: 5800343. DOI: 10.1136/oemed-2017-104529. View