Electron-capture Gas Chromatographic Analysis of Beta-phenylethylamine in Tissues and Body Fluids Using Pentafluorobenzenesulfonyl Chloride for Derivatization

Overview

Journal J Chromatogr

Date 1986 Sep 5

PMID 3760080

Citations 5

Authors

G B Baker

T S Rao

R T Coutts

Affiliations

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Abstract

A gas chromatographic procedure is described for the analysis of beta-phenylethylamine (PEA) in tissues and body fluids. The method involves the use of pentafluorobenzenesulfonyl chloride for extraction and derivatization of PEA. This is followed by separation and analysis of the derivatized amine on a gas chromatograph equipped with a fused-silica capillary column and an electron-capture detector. The procedure is rapid, provides a stable and sensitive derivative, and has been applied to analysis of PEA in brain, heart, kidney, liver, lung, spleen and blood from the rat and urine from human subjects.

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Baker G, Bornstein R, Yeragani V Neurochem Res. 1993; 18(9):951-6.

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Urinary excretion of bioactive amines and their metabolites in psychiatric patients receiving phenelzine.

McKenna K, Baker G, Coutts R Neurochem Res. 1993; 18(9):1023-7.

PMID: 8232718 DOI: 10.1007/BF00966763.

Pharmacokinetic and neurochemical studies on N-propargyl-2-phenylethylamine, a prodrug of 2-phenylethylamine.

Rao T, Baker G, Coutts R Naunyn Schmiedebergs Arch Pharmacol. 1987; 336(1):25-32.

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Neurochemical and neuropharmacological properties of 4-fluorotranylcypromine.

Coutts R, Rao T, Baker G, Micetich R, Hall T Cell Mol Neurobiol. 1987; 7(3):271-90.

PMID: 3440283 PMC: 11567413. DOI: 10.1007/BF00711304.

Neuropharmacological and neurochemical properties of N-(2-cyanoethyl)-2-phenylethylamine, a prodrug of 2-phenylethylamine.

Baker G, Coutts R, Rao T Br J Pharmacol. 1987; 92(2):243-55.

PMID: 2890391 PMC: 1853650. DOI: 10.1111/j.1476-5381.1987.tb11318.x.