A Potential Therapeutic Drug for Osteoporosis: Prospect for Osteogenic LncRNAs

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Aug 21

PMID 37600711

Authors

Fanjin Meng

Yang Yu

Ye Tian

Meng Deng

Kaiyuan Zheng

Xiaolan Guo

Beilei Zeng

Jingjia Li

Airong Qian

Chong Yin

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (LncRNAs) play essential roles in multiple physiological processes including bone formation. Investigators have revealed that LncRNAs regulated bone formation through various signaling pathways and micro RNAs (miRNAs). However, several problems exist in current research studies on osteogenic LncRNAs, including sophisticated techniques, high cost for experiment, as well as low homology of LncRNAs between animal model and human, which hindered translational medicine research. Moreover, compared with gene editing, LncRNAs would only lead to inhibition of target genes rather than completely knocking them out. As the studies on osteogenic LncRNA gradually proceed, some of these problems have turned osteogenic LncRNA research studies into slump. This review described some new techniques and innovative ideas to address these problems. Although investigations on osteogenic LncRNAs still have obtacles to overcome, LncRNA will work as a promising therapeutic drug for osteoporosis in the near future.

Citing Articles

Molecular and Cellular Mechanisms of Osteoporosis.

Zhivodernikov I, Kirichenko T, Markina Y, Postnov A, Markin A Int J Mol Sci. 2023; 24(21).

PMID: 37958752 PMC: 10648156. DOI: 10.3390/ijms242115772.

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