Enhances Cervical Cancer Metastasis Through -mediated Activation of / Signaling

Overview

Journal iScience

Publisher Cell Press

Date 2023 Aug 21

PMID 37599824

Authors

Yifang Mao

Xingyu Jiang

Peng Guo

Ying Ouyang

Xiangfu Chen

Meng Xia

Lixin Wu

Zihao Tang

Tianyi Liang

Yue Li

Mian He

Affiliations

Soon will be listed here.

Abstract

Metastasis in cervical cancer (CC) has a significant negative impact on patient survival, highlighting the urgent need for investigation in this area. In this study, we identified significant overexpression of zinc finger, X-linked, duplicated family member C () in CC tissue with metastasis, which correlates with poor outcomes for CC patients. We observed that overexpression of promotes, while silencing of inhibits the metastasis of CC cells both and . Additionally, our research demonstrated that activated / signaling pathway, leading to enhanced cytoskeleton remodeling in CC cells. Besides, we found that plays an essential role in the activation of on the / signaling pathway by stabilizing mRNA. These findings reveal a mechanism whereby promotes the cervical cancer metastasis by targeting // pathway.

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