Assessment of Proxy-reported Responses As Predictors of Motor and Sensory Peripheral Neuropathy in Children with B-lymphoblastic Leukemia

Overview

Journal Pediatr Blood Cancer

Specialties Hematology
Oncology
Pediatrics

Date 2023 Aug 17

PMID 37592363

Authors

Rozalyn L Rodwin

Natalie J DelRocco

Emily Hibbitts

Meenakshi Devidas

Moira K Whitley

Caroline E Mohrmann

Reuven J Schore

Elizabeth Raetz

Naomi J Winick

Stephen P Hunger

Mignon L Loh

Marilyn J Hockenberry

Xiaomei Ma

Anne L Angiolillo

Kirsten K Ness

John A Kairalla

Nina S Kadan-Lottick

Affiliations

Soon will be listed here.

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64-0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54-0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

Citing Articles

Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia.

Mogensen N, Kreicbergs U, Albertsen B, Lahteenmaki P, Heyman M, Harila A Hemasphere. 2024; 8(7):e124.

PMID: 39006374 PMC: 11241145. DOI: 10.1002/hem3.124.

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