The Role of Metabolism in Cellular Quiescence

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2023 Aug 17

PMID 37589342

Authors

Yipeng Du

Parul Gupta

Shenlu Qin

Matthew Sieber

Affiliations

Soon will be listed here.

Abstract

Cellular quiescence is a dormant, non-dividing cell state characterized by significant shifts in physiology and metabolism. Quiescence plays essential roles in a wide variety of biological processes, ranging from microbial sporulation to human reproduction and wound repair. Moreover, when the regulation of quiescence is disrupted, it can drive cancer growth and compromise tissue regeneration after injury. In this Review, we examine the dynamic changes in metabolism that drive and support dormant and transiently quiescent cells, including spores, oocytes and adult stem cells. We begin by defining quiescent cells and discussing their roles in key biological processes. We then examine metabolic factors that influence cellular quiescence in both healthy and disease contexts, and how these could be leveraged in the treatment of cancer.

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