Histological and Histochemical Changes in the Columnar Lined (Barrett's) Oesophagus

Overview

Journal Gut

Specialty Gastroenterology

Date 1986 Sep 1

PMID 3758820

Citations 20

Authors

G A Rothery

J E Patterson

C J Stoddard

D W Day

Affiliations

Soon will be listed here.

Abstract

Multiple endoscopic specimens were obtained from 58 patients with a columnar lined gesophagus to study the histological and histochemical features of this metaplastic epithelium. Five patients (8.6%) had presented with a primary oesophageal adenocarcinoma. Three different epithelial types, junctional, atrophic fundic and intestinal were identified. Twenty two (38%) patients had just one type of epithelium present, the other 36 (62%) having a combination of two or three different types. Intestinal type of epithelium, either alone or in combination with gastric type epithelium was present in 48 (83%) patients. In every case this intestinal type epithelium took the form of an incompletely differentiated variant of intestinal metaplasia, although complete intestinal metaplasia as a focal change was also present in 14 of these patients. Histochemically, sulphomucins were present in the biopsies of 43 (74%) of the patients studied. They were seen in both goblet and columnar mucous cells with almost equal frequency. Incomplete intestinal metaplasia with sulphomucin production was present in four of the five patients with an oesophageal adenocarcinoma. In the columnar lined oesophagus sulphomucin production is common and its presence does not help to identify those individuals at particular risk of developing an adenocarcinoma.

Citing Articles

The length of the Barrett's mucosa in baboons, revisited.

Rubio C, Nilsson J, Owston M, Dick Jr E Anticancer Res. 2012; 32(8):3115-8.

PMID: 22843881 PMC: 3468325.

Further studies on Barretts mucosa in baboons: metaplastic glandular cells produce sialomucin.

Rubio C, Owston M, Orrego A, Dick Jr E Anticancer Res. 2010; 30(10):4123-6.

PMID: 21036729 PMC: 3468319.

Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study.

Szachnowicz S, Cecconello I, Ribeiro U, Iriya K, El Ibrahim R, Takeda F World J Surg Oncol. 2009; 7:27.

PMID: 19272137 PMC: 2662840. DOI: 10.1186/1477-7819-7-27.

Barrett's oesophagus: from metaplasia to dysplasia and cancer.

Flejou J Gut. 2005; 54 Suppl 1:i6-12.

PMID: 15711008 PMC: 1867794. DOI: 10.1136/gut.2004.041525.

Barrett's esophagus: histopathologic definitions and diagnostic criteria.

Mueller J, Werner M, Stolte M World J Surg. 2004; 28(2):148-54.

PMID: 14727064 DOI: 10.1007/s00268-003-7050-4.

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