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Bladder Smooth Muscle Dysfunction in Patients with Irritable Bowel Syndrome

Overview
Journal Gut
Specialty Gastroenterology
Date 1986 Sep 1
PMID 3758813
Citations 34
Authors
P J Whorwell
E W Lupton
D Erduran
K Wilson
Affiliations
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Abstract

Urodynamic studies were carried out on 30 patients with irritable bowel syndrome and 30 matched controls. Fifty per cent of the irritable bowel patients compared with only 13% of the control group had evidence of bladder dysfunction (p = 0.006). In the irritable bowel group detrusor instability was observed in 10 patients compared with only one control subject (p = 0.008). A steep cystometrogram occurred in five irritable bowel patients and three controls (NS). Detrusor instability was most common in patients with a bowel habit characterised by alternating constipation and diarrhoea. This is the first study to provide objective evidence that patients with irritable bowel syndrome may have a disorder of smooth muscle or its innervation that is not confined to the gastrointestinal system.

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References
1.
Bates C . Continence and incontinence. A clinical study of the dynamics of voiding and of the sphincter mechanism. Ann R Coll Surg Engl. 1971; 49(1):18-35. PMC: 2387980. View
2.
Ritchie J . The irritable bowel syndrome. Part II: manometric and cineradiographic studies. Clin Gastroenterol. 1977; 6(3):622-41. View
3.
Taylor I, Darby C, Hammond P, Basu P . Is there a myoelectrical abnormality in the irritable colon syndrome?. Gut. 1978; 19(5):391-5. PMC: 1412107. DOI: 10.1136/gut.19.5.391. View
4.
Warwick R . Observations on the function and dysfunction of the sphincter and detrusor mechanisms. Urol Clin North Am. 1979; 6(1):13-30. View
5.
Thompson D, Laidlow J, Wingate D . Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon. Lancet. 1979; 2(8156-8157):1321-3. DOI: 10.1016/s0140-6736(79)92811-3. View