Resting Heart Rate (variability) and Cognition Relationships Reveal Cognitively Healthy Individuals with Pathological Amyloid/tau Ratio

Overview

Journal Front Epidemiol

Specialty Public Health

Date 2023 Aug 17

PMID 37587981

Authors

Cathleen Molloy

Elizabeth H Choy

Rebecca J Arechavala

David Buennagel

Anne Nolty

Mitchell R Spezzaferri

Caleb Sin

Shant Rising

Jeremy Yu

Abdulhakim Al-Ezzi

Michael T Kleinman

Robert A Kloner

Xianghong Arakaki

Affiliations

Soon will be listed here.

Abstract

Introduction: Resting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in older individuals with early Alzheimer's disease (AD) pathology. This study explores relationships of the HR, HRV, and cognition in cognitively healthy individuals with pathological amyloid/tau ratio (CH-PATs) in cerebral spinal fluid (CSF) compared to those with normal ratio (CH-NATs).

Methods: We examined therelationshipsbetween1) resting HR and Mini-Mental State Examination (MMSE); 2) resting HR and brain processing during Stroop interference; and 3) resting vagally mediated HRV (vmHRV) and task switching performance.

Results: Our studies showed that compared to CH-NATs, those CH-PATs with higher resting HR presented with lower MMSE, and less brain activation during interference processing. In addition, resting vmHRV was significantly correlated with task switching accuracy in CH-NATs, but not in CH-PATs.

Discussion: Thesethreedifferenttestsindicatedysfunctionalheart-brainconnections in CH-PATs, suggesting a potential cardio-cerebral dysfunctional integration.

Citing Articles

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Disrupted brain functional connectivity as early signature in cognitively healthy individuals with pathological CSF amyloid/tau.

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