Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis

Overview

Journal J Ind Microbiol Biotechnol

Publisher Oxford University Press

Specialty Biotechnology

Date 2023 Aug 16

PMID 37587009

Authors

Amir Y Alwali

Elizabeth I Parkinson

Affiliations

Soon will be listed here.

Abstract

One-sentence Summary: This review describes chemical elicitors of actinobacteria natural products described to date and the proposed mechanisms of induction.

Citing Articles

Macrogenomic Analysis Reveals Soil Microbial Diversity in Different Regions of the Antarctic Peninsula.

Qu J, Lu X, Liu T, Qu Y, Xing Z, Wang S Microorganisms. 2025; 12(12.

PMID: 39770646 PMC: 11677454. DOI: 10.3390/microorganisms12122444.

Regulatory Effects of Alhagi Honey Small-Molecule Sugars on Growth Performance and Intestinal Microbiota of Lambs.

Li J, Kudereti T, Wusiman A, Abula S, He X, Li J Animals (Basel). 2024; 14(16).

PMID: 39199936 PMC: 11350646. DOI: 10.3390/ani14162402.

Causal relationship between gut microbiota and ankylosing spondylitis and potential mediating role of inflammatory cytokines: A mendelian randomization study.

Du X, Li H, Zhao H, Cui S, Sun X, Tan X PLoS One. 2024; 19(7):e0306792.

PMID: 39083521 PMC: 11290680. DOI: 10.1371/journal.pone.0306792.

The distribution characteristics of aerosol bacteria in different types of sheepfolds.

Wang J, Yu Y, Raheem A, Guo Y, Ma Q, Lu D Front Vet Sci. 2024; 11:1348850.

PMID: 38420208 PMC: 10900508. DOI: 10.3389/fvets.2024.1348850.

References

Hsiao N, Nakayama S, Merlo M, de Vries M, Bunet R, Kitani S . Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter system. Chem Biol. 2009; 16(9):951-60. DOI: 10.1016/j.chembiol.2009.08.010. View

Stratton K, Bush M, Chandra G, Stevenson C, Findlay K, Schlimpert S . Genome-Wide Identification of the LexA-Mediated DNA Damage Response in Streptomyces venezuelae. J Bacteriol. 2022; 204(8):e0010822. PMC: 9380542. DOI: 10.1128/jb.00108-22. View

Wilbanks L, Hennigan H, Martinez-Brokaw C, Lakkis H, Thormann S, Eggly A . Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction. ACS Chem Biol. 2023; 18(7):1624-1631. PMC: 10368014. DOI: 10.1021/acschembio.3c00241. View

Li Y, Lee S, Han E, Seyedsayamdost M . Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus. Angew Chem Int Ed Engl. 2022; 61(39):e202208573. PMC: 9489664. DOI: 10.1002/anie.202208573. View

Cuthbertson L, Nodwell J . The TetR family of regulators. Microbiol Mol Biol Rev. 2013; 77(3):440-75. PMC: 3811609. DOI: 10.1128/MMBR.00018-13. View

Calvelo V, Crisante D, Elliot M, Nodwell J . The ARC2 response in requires the global regulatory genes and . Microbiology (Reading). 2021; 167(5). DOI: 10.1099/mic.0.001047. View

Hesketh A, Ochi K . A novel method for improving Streptomyces coelicolor A3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin. J Antibiot (Tokyo). 1997; 50(6):532-5. DOI: 10.7164/antibiotics.50.532. View

van Bergeijk D, Elsayed S, Du C, Nunez Santiago I, Roseboom A, Zhang L . The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces. Commun Chem. 2023; 5(1):14. PMC: 9814775. DOI: 10.1038/s42004-022-00632-4. View

Tenson T, Lovmar M, Ehrenberg M . The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol. 2003; 330(5):1005-14. DOI: 10.1016/s0022-2836(03)00662-4. View

10.

Xu F, Nazari B, Moon K, Bushin L, Seyedsayamdost M . Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc. 2017; 139(27):9203-9212. PMC: 5617735. DOI: 10.1021/jacs.7b02716. View

11.

Wang W, Zhang J, Liu X, Li D, Li Y, Tian Y . Identification of a butenolide signaling system that regulates nikkomycin biosynthesis in . J Biol Chem. 2018; 293(52):20029-20040. PMC: 6311496. DOI: 10.1074/jbc.RA118.005667. View

12.

Polkade A, Mantri S, Patwekar U, Jangid K . Quorum Sensing: An Under-Explored Phenomenon in the Phylum Actinobacteria. Front Microbiol. 2016; 7:131. PMC: 4748050. DOI: 10.3389/fmicb.2016.00131. View

13.

Zhu J, Sun D, Liu W, Chen Z, Li J, Wen Y . AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. Mol Microbiol. 2016; 102(4):562-578. DOI: 10.1111/mmi.13479. View

14.

Tan G, Bai L, Zhong J . Exogenous 1,4-butyrolactone stimulates A-factor-like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008. Biotechnol Bioeng. 2013; 110(11):2984-93. DOI: 10.1002/bit.24965. View

15.

Nishimura K, Hosaka T, Tokuyama S, Okamoto S, Ochi K . Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). J Bacteriol. 2007; 189(10):3876-83. PMC: 1913335. DOI: 10.1128/JB.01776-06. View

16.

Arakawa K, Tsuda N, Taniguchi A, Kinashi H . The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and lankamycin production in Streptomyces rochei. Chembiochem. 2012; 13(10):1447-57. DOI: 10.1002/cbic.201200149. View

17.

Ahmed S, Craney A, Pimentel-Elardo S, Nodwell J . A synthetic, species-specific activator of secondary metabolism and sporulation in Streptomyces coelicolor. Chembiochem. 2012; 14(1):83-91. DOI: 10.1002/cbic.201200619. View

18.

Imai Y, Sato S, Tanaka Y, Ochi K, Hosaka T . Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp. Appl Environ Microbiol. 2015; 81(11):3869-79. PMC: 4421039. DOI: 10.1128/AEM.04214-14. View

19.

Newman D, Cragg G . Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J Nat Prod. 2020; 83(3):770-803. DOI: 10.1021/acs.jnatprod.9b01285. View

20.

Stone K, Strominger J . Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate. Proc Natl Acad Sci U S A. 1971; 68(12):3223-7. PMC: 389626. DOI: 10.1073/pnas.68.12.3223. View