Does Resveratrol Reduce Cisplatin-induced Ovarian Damage?

Overview

Journal Rev Assoc Med Bras (1992)

Specialty General Medicine

Date 2023 Aug 16

PMID 37585992

Authors

Baris Ciplak

Eyup Gokhan Turmus

Ozlem Kara

Gulcin Daglioglu

Mehmet Murat Altindag

Yavuz Simsek

Yusuf Kenan Daglioglu

Mustafa Kara

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models.

Methods: A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats' malondialdehyde, catalase, and superoxide dismutase levels were determined.

Results: The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001).

Conclusion: The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models.

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