Causal Relationship Between Osteoarthritis with Atrial Fibrillation and Coronary Atherosclerosis: a Bidirectional Mendelian Randomization Study of European Ancestry

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2023 Aug 16

PMID 37583579

Authors

Meng Yin

Wenchang Xu

Jixiang Pang

Siwen Xie

Mengting Xiang

Bin Shi

Hua Fan

Gongchang Yu

Affiliations

Soon will be listed here.

Abstract

Background: Osteoarthritis (OA) is a degenerative disease with high prevalence. Some observational studies have shown that patients with osteoarthritis often have co-existing cardiovascular diseases (CVD) such as atrial fibrillation (AF) and coronary atherosclerosis (CA). However, there is still a lack of stronger evidence confirming the association between osteoarthritis and cardiovascular disease. In this study, we used a bidirectional two-sample Mendelian randomization study to investigate the relationship between OA with AF and CA.

Methods: OA data from the UK Biobank and arcOGEN (Arthritis Research UK Osteoarthritis Genetics, a study that aimed to find genetic determinants of osteoarthritis and elucidate the genetic architecture of the disease) integration were selected for the study ( = 417,596), AF data were obtained from six studies ( = 1,030,836), and coronary atherosclerosis data were derived from the FinnGen ( = 218,792). MR analysis was performed primarily using the Inverse variance weighted (IVW) method, with MR Egger, weighted median, simple mode, weighted mode as supplements, sensitivity analysis was performed using Cochran Q statistic, and leave-one-out analysis.

Results: We found that OA and AF were positively associated [IVW: OR (95% CI): 1.11 (1.04, 1.19), = 0.002], while OA and CA were negatively associated [IVW: OR (95% CI): 0.88 (0.79, 0.98), = 0.02]. In the reverse MR analysis, no effect of AF on OA was found [IVW: OR (95% CI): 1.00 (0.97, 1.03), = 0.84], meanwhile, CA and OA were found to be associated negatively [IVW: OR (95% CI): 0.95 (0.92, 0.99), = 0.01]. No violations of MR assumptions were found in the sensitivity analysis.

Conclusion: This research confirms that OA is a risk factor for AF, and there is a mutual protective factor between OA and CA. However, further studies are still necessary to elucidate the underlying mechanisms.

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