Topically Applied Fullerenols Protect Against Radiation Dermatitis by Scavenging Reactive Oxygen Species

Overview

Journal Discov Nano

Date 2023 Aug 15

PMID 37581715

Authors

Hanying Yin

You Gao

Weiguang Chen

Chen Tang

Zihan Zhu

Kun Li

Siyu Xia

Changshun Han

Xiaoyan Ding

Fengkai Ruan

Hanrui Tian

Changfeng Zhu

Suyuan Xie

Zhenghong Zuo

Lixin Liao

Chengyong He

Affiliations

Soon will be listed here.

Abstract

Adverse skin reactions caused by ionizing radiation are collectively called radiation dermatitis (RD), and the use of nanomedicine is an attractive approach to this condition. Therefore, we designed and large-scale synthesized fullerenols that showed free radical scavenging ability in vitro. Next, we pretreated X-ray-exposed cells with fullerenols. The results showed that pretreatment with fullerenols significantly scavenged intracellular reactive oxygen species (ROS) produced and enhanced the antioxidant capacity, protecting skin cells from X-ray-induced DNA damage and apoptosis. Moreover, we induced RD in mice by applying 30 Gy of X-ray irradiation, followed by treatment with fullerenols. We found that after treatment, the RD scores dropped, and the histological results systematically demonstrated that topically applied fullerenols could reduce radiation-induced skin epidermal thickening, collagen deposition and skin appendage damage and promote hair regeneration after 35 days. Compared with Trolamine cream, a typical RD drug, fullerenols showed superior radiation protection. Overall, the in vitro and in vivo experiments proved that fullerenols agents against RD.

Citing Articles

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