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Pharmacokinetics of Fluocortolone in Man

Overview
Journal Eur J Clin Pharmacol
Specialty Pharmacology
Date 1986 Jan 1
PMID 3758149
Citations 2
Authors
U F Legler
Affiliations
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Abstract

The kinetics of the synthetic corticoid fluocortolone was determined in 9 healthy female volunteers after a single oral dose of 20 mg. The maximal plasma level fluocortolone (Cmax) of 202 +/- 70 ng/ml occurred within 85 +/- 32 min of oral intake after which it declined monoexponentially. Total plasma clearance was 6.48 +/- 2.07 ml/min X kg and the clearance of unbound fluocortolone was 60.38 +/- 26.67 ml/min X kg. Plasma protein binding was 83 to 95%. The volume of distribution at steady-state was 1.01 +/- 0.341/kg for total fluocortolone and 11.21 +/- 3.771/kg for unbound drug. The results of the study characterize the kinetics of unbound fluocortolone for the first time. In addition, the kinetics of total fluocortolone presented here confirm values calculated previously.

Citing Articles

Pharmacodynamic modeling of cortisol suppression from fluocortolone.

Lew K, Jusko W Eur J Clin Pharmacol. 1993; 45(6):581-3.

PMID: 8157047 DOI: 10.1007/BF00315319.

Lack of impairment of fluocortolone disposition in oral contraceptive users.

Legler U Eur J Clin Pharmacol. 1988; 35(1):101-3.

PMID: 3220090 DOI: 10.1007/BF00555517.

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