Effects of Spironolactone on Serum and Muscle Electrolytes in Patients on Long-term Diuretic Therapy for Congestive Heart Failure And/or Arterial Hypertension

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1986 Jan 1

PMID 3758141

Citations 9

Authors

T Dyckner

P O Wester

L Widman

Affiliations

Soon will be listed here.

Abstract

The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.

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