Altered Interhemispheric Functional Connectivity in Patients with Comitant Exotropia Before and After Surgery: a Resting-state FMRI Study

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2023 Aug 14

PMID 37576471

Authors

Xiang-Xun Chen

Wen Chen

Hao Hu

Meng Zhao

Hu Liu

Xiao-Quan Xu

Fei-Yun Wu

Jie Wang

Affiliations

Soon will be listed here.

Abstract

Purpose: To assess the interhemispheric homotopic connectivity alterations in patients with comitant exotropia (CE) before and after surgery, using resting-state functional magnetic resonance imaging (rs-fMRI) with voxel-mirrored homotopic connectivity (VMHC).

Methods: Thirty-four patients with CE and twenty-four well-matched healthy controls (HCs) were enrolled to undergo a preoperative rs-fMRI scan. The rs-fMRI scan was performed again in twenty-four patients 1 month after surgery. The VMHC method was applied to evaluate the group differences of interhemispheric functional connectivity. The correlations between VMHC values and clinical variables were analyzed in the patient group.

Results: Compared with HCs, 34 patients with CE showed significantly increased VMHC values in occipital lobe (cuneus/superior occipital gyrus/middle occipital gyrus/calcarine), cerebellar area 8/cerebellar Crus1 area, and cerebellar Crus1 area. In CE group, VMHC in the cuneus was positively correlated with stereoacuity ( = 0.417, = 0.014), meanwhile VMHC in the cerebellar Crus1 area was positively correlated with stereoacuity ( = 0.395, = 0.021). One month after surgery, the 24 CE patients with follow-up showed decreased VMHC values in the cuneus and superior occipital gyrus compared with preoperative collection, meanwhile, non-significant difference compared with HCs.

Conclusion: Our study revealed the interhemispheric homotopic connectivity changes of patients with CE in the occipital lobe and cerebellum before and after surgery. The findings may provide a new perspective for the neurological alterations of CE.

References

Chen F, Hu Z, Liu H, Zhen F, Liu C, Li Q . Altered Homotopic Connectivity in the Cerebellum Predicts Stereopsis Dysfunction in Patients With Comitant Exotropia. Front Hum Neurosci. 2022; 16:917769. PMC: 9201504. DOI: 10.3389/fnhum.2022.917769. View

Herzfeld D, Kojima Y, Soetedjo R, Shadmehr R . Encoding of action by the Purkinje cells of the cerebellum. Nature. 2015; 526(7573):439-42. PMC: 4859153. DOI: 10.1038/nature15693. View

Tong Y, Zhong Y, Liu H, Huang X . Disrupted interhemispheric functional connectivity in primary angle-closure glaucoma: a functional MRI study: voxel-mirrored homotopic connectivity in primary angle-closure glaucoma patients. Neuroreport. 2022; 33(14):604-611. DOI: 10.1097/WNR.0000000000001823. View

Pennefather P, Clarke M, Strong N, Cottrell D, Dutton J, Tin W . Risk factors for strabismus in children born before 32 weeks' gestation. Br J Ophthalmol. 1999; 83(5):514-8. PMC: 1723046. DOI: 10.1136/bjo.83.5.514. View

Zuo X, Kelly C, Di Martino A, Mennes M, Margulies D, Bangaru S . Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neurosci. 2010; 30(45):15034-43. PMC: 2997358. DOI: 10.1523/JNEUROSCI.2612-10.2010. View

Livir-Rallatos G, Gunton K, Calhoun J . Surgical results in large-angle exotropia. J AAPOS. 2002; 6(2):77-80. DOI: 10.1067/mpa.2002.122059. View

Zhang H, Shan A, Gan C, Zhang L, Wang L, Sun H . Impaired interhemispheric synchrony in Parkinson's disease patients with apathy. J Affect Disord. 2022; 318:283-290. DOI: 10.1016/j.jad.2022.09.006. View

Chao-Gan Y, Yu-Feng Z . DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Front Syst Neurosci. 2010; 4:13. PMC: 2889691. DOI: 10.3389/fnsys.2010.00013. View

Eklund A, Nichols T, Knutsson H . Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci U S A. 2016; 113(28):7900-5. PMC: 4948312. DOI: 10.1073/pnas.1602413113. View

10.

Maconachie G, Gottlob I, McLean R . Risk factors and genetics in common comitant strabismus: a systematic review of the literature. JAMA Ophthalmol. 2013; 131(9):1179-86. DOI: 10.1001/jamaophthalmol.2013.4001. View

11.

Lv H, Wang Z, Tong E, Williams L, Zaharchuk G, Zeineh M . Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know. AJNR Am J Neuroradiol. 2018; 39(8):1390-1399. PMC: 6051935. DOI: 10.3174/ajnr.A5527. View

12.

Buffenn A . The impact of strabismus on psychosocial heath and quality of life: a systematic review. Surv Ophthalmol. 2021; 66(6):1051-1064. DOI: 10.1016/j.survophthal.2021.03.005. View

13.

Ringach D, Hawken M, Shapley R . Binocular eye movements caused by the perception of three-dimensional structure from motion. Vision Res. 1996; 36(10):1479-92. DOI: 10.1016/0042-6989(95)00285-5. View

14.

Birch E, Fawcett S, Morale S, Weakley Jr D, Wheaton D . Risk factors for accommodative esotropia among hypermetropic children. Invest Ophthalmol Vis Sci. 2005; 46(2):526-9. DOI: 10.1167/iovs.04-0618. View

15.

Ashburner J . SPM: a history. Neuroimage. 2011; 62(2):791-800. PMC: 3480642. DOI: 10.1016/j.neuroimage.2011.10.025. View

16.

Gulyas B, Roland P . Processing and analysis of form, colour and binocular disparity in the human brain: functional anatomy by positron emission tomography. Eur J Neurosci. 1994; 6(12):1811-28. DOI: 10.1111/j.1460-9568.1994.tb00574.x. View

17.

Oystreck D, Lyons C . Comitant strabismus: Perspectives, present and future. Saudi J Ophthalmol. 2013; 26(3):265-70. PMC: 3729504. DOI: 10.1016/j.sjopt.2012.05.002. View

18.

Lidzba K, Wilke M, Staudt M, Krageloh-Mann I, Grodd W . Reorganization of the cerebro-cerebellar network of language production in patients with congenital left-hemispheric brain lesions. Brain Lang. 2007; 106(3):204-10. DOI: 10.1016/j.bandl.2007.11.003. View

19.

Yan X, Wang Y, Xu L, Liu Y, Song S, Ding K . Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study. Curr Eye Res. 2018; 44(3):316-323. DOI: 10.1080/02713683.2018.1540642. View

20.

Peng J, Yao F, Li Q, Ge Q, Shi W, Su T . Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study. Sci Rep. 2021; 11(1):15059. PMC: 8302749. DOI: 10.1038/s41598-021-92281-1. View