Nutritional Status and Quality of Life Among Breast Cancer Patients Undergoing Treatment in Addis Ababa, Ethiopia

Overview

Journal BMC Womens Health

Publisher Biomed Central

Specialty Gynecology & Obstetrics

Date 2023 Aug 11

PMID 37568125

Authors

Ruth Adam

Werissaw Haileselassie

Nabel Solomon

Yakob Desalegn

Wondemagegnhu Tigeneh

Yisihak Suga

Samson Gebremedhin

Affiliations

Soon will be listed here.

Abstract

Background: The prevalence of malnutrition in cancer patients ranges from 30 to 60%. While it is known that malnutrition is prevalent among cancer patients, the relationship between undernutrition and quality of life among breast cancer patients has not been adequately explored. Therefore, the present study was aimed at assessing the association between undernutrition and quality of life among Breast Cancer patients under treatment in Addis Ababa, Ethiopia.

Methods: A cross-sectional study on breast cancer patients under treatment at the outpatient and in-patient departments of oncology centers of two tertiary hospitals in Addis Ababa - Tikur Anbessa Specialized Hospital (TASH) and St. Paul Millennium Medical College (SPHMMC) oncology was conducted from May 12 to August 26,2020. Nutritional status was assessed using Subjective Global Assessment (SGA) screening tool. Quality of life was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Cancer 30 (EORTC QLQ C30) a standard quality of life measurement scale for cancer patients. To determine the relationship between quality of life scores and nutritional status multivariable linear regression was fitted.

Results: A total of 411 breast cancer patients with mean age of 44.4 (± 11.47) years. And 393 (95.6%) of them female were included in the study. A high prevalence of moderate 127 (30.9%) and severe 106 (25.8%) malnutrition was observed. Moderate (β = -9.21 CI (- 14.59, - 4.67)) and severe (β = -17.81 CI (- 16.6, 2 - 2.91)) malnutrition were negatively associated with the overall quality of life. Malnutrition also showed negative associations with all domains of functional status (P < 0.05) and strong positive associations with symptom scores covered in the EORTC QLQ C-30 (P < 0.05).

Conclusion: This study indicated that malnutrition is a major problem among breast cancer patients and the nutritional status breast cancer patients was related to their quality of life….

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References

Zhu C, Wang B, Gao Y, Ma X . Prevalence and relationship of malnutrition and distress in patients with Cancer using questionnaires. BMC Cancer. 2018; 18(1):1272. PMC: 6299972. DOI: 10.1186/s12885-018-5176-x. View

Trabal J, Leyes P, Forga M, Hervas S . Quality of life, dietary intake and nutritional status assessment in hospital admitted cancer patients. Nutr Hosp. 2006; 21(4):505-10. View

Memirie S, Kifle Habtemariam M, Asefa M, Deressa B, Abayneh G, Tsegaye B . Estimates of Cancer Incidence in Ethiopia in 2015 Using Population-Based Registry Data. J Glob Oncol. 2018; 4:1-11. PMC: 6223441. DOI: 10.1200/JGO.17.00175. View

Lis C, Gupta D, Lammersfeld C, Markman M, Vashi P . Role of nutritional status in predicting quality of life outcomes in cancer--a systematic review of the epidemiological literature. Nutr J. 2012; 11:27. PMC: 3408376. DOI: 10.1186/1475-2891-11-27. View

Muscaritoli M, Lucia S, Farcomeni A, Lorusso V, Saracino V, Barone C . Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study. Oncotarget. 2017; 8(45):79884-79896. PMC: 5668103. DOI: 10.18632/oncotarget.20168. View

Custodio I, da Costa Marinho E, Gontijo C, Pereira T, Paiva C, Maia Y . Impact of Chemotherapy on Diet and Nutritional Status of Women with Breast Cancer: A Prospective Study. PLoS One. 2016; 11(6):e0157113. PMC: 4911080. DOI: 10.1371/journal.pone.0157113. View

Dow K, Ferrell B, Leigh S, Ly J, Gulasekaram P . An evaluation of the quality of life among long-term survivors of breast cancer. Breast Cancer Res Treat. 1996; 39(3):261-73. DOI: 10.1007/BF01806154. View

Lu Shin K, Mun C, Shariff Z . Nutrition Indicators, Physical Function, and Health-Related Quality of Life in Breast Cancer Patients. Asian Pac J Cancer Prev. 2020; 21(7):1939-1950. PMC: 7573431. DOI: 10.31557/APJCP.2020.21.7.1939. View

Nourissat A, Vasson M, Merrouche Y, Bouteloup C, Goutte M, Mille D . Relationship between nutritional status and quality of life in patients with cancer. Eur J Cancer. 2008; 44(9):1238-42. DOI: 10.1016/j.ejca.2008.04.006. View

10.

Basaran G, Turhal N, Cabuk D, Yurt N, Yurtseven G, Gumus M . Weight gain after adjuvant chemotherapy in patients with early breast cancer in Istanbul Turkey. Med Oncol. 2010; 28(2):409-15. DOI: 10.1007/s12032-010-9463-x. View

11.

Lua P, Salihah N, Mazlan N . Nutritional status and health-related quality of life of breast cancer patients on chemotherapy. Malays J Nutr. 2014; 18(2):173-84. View

12.

Yaw Y, Shariff Z, Kandiah M, Mun C, Mohd Yusof R, Othman Z . Weight changes and lifestyle behaviors in women after breast cancer diagnosis: a cross-sectional study. BMC Public Health. 2011; 11:309. PMC: 3121627. DOI: 10.1186/1471-2458-11-309. View

13.

Vergara N, Montoya J, Luna H, Amparo J, Cristal-Luna G . Quality of life and nutritional status among cancer patients on chemotherapy. Oman Med J. 2013; 28(4):270-4. PMC: 3725251. DOI: 10.5001/omj.2013.75. View

14.

Gamper E, Giesinger J, Oberguggenberger A, Kemmler G, Wintner L, Gattringer K . Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: prevalence, course of severity, and quality of life correlates. Acta Oncol. 2011; 51(4):490-6. DOI: 10.3109/0284186X.2011.633554. View

15.

Kantelhardt E, Zerche P, Mathewos A, Trocchi P, Addissie A, Aynalem A . Breast cancer survival in Ethiopia: a cohort study of 1,070 women. Int J Cancer. 2013; 135(3):702-9. DOI: 10.1002/ijc.28691. View

16.

Zorlini R, Akemi Abe Cairo A, Salete Costa Gurgel M . Nutritional status of patients with gynecologic and breast cancer. Nutr Hosp. 2009; 23(6):577-83. View

17.

Pressoir M, Desne S, Berchery D, Rossignol G, Poiree B, Meslier M . Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres. Br J Cancer. 2010; 102(6):966-71. PMC: 2844030. DOI: 10.1038/sj.bjc.6605578. View

18.

Pisegna J, Xu M, Spees C, Krok-Schoen J . Mental health-related quality of life is associated with diet quality among survivors of breast cancer. Support Care Cancer. 2020; 29(4):2021-2028. DOI: 10.1007/s00520-020-05698-1. View

19.

Ayana B, Negash S, Yusuf L, Tigeneh W, Haile D . Reliability and Validity of Amharic Version of EORTC QLQ-C 30 Questionnaire among Gynecological Cancer Patients in Ethiopia. PLoS One. 2016; 11(6):e0157359. PMC: 4909272. DOI: 10.1371/journal.pone.0157359. View

20.

Luoma M, Hakamies-Blomqvist L . The meaning of quality of life in patients being treated for advanced breast cancer: a qualitative study. Psychooncology. 2004; 13(10):729-39. DOI: 10.1002/pon.788. View